Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA transcripts regulate G-quadruplex landscapes through G-loop formation

ABSTRACT: RNA transcripts regulate G-quadruplex landscapes through G-loop formation

PROVIDER: PRJNA1114771 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR29133506_1.fastq.gz	Fastqsanger.gz
	SRR29133506_2.fastq.gz	Fastqsanger.gz
	SRR29133507_1.fastq.gz	Fastqsanger.gz
	SRR29133507_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 31

Similar Datasets

RNA transcripts regulate G-quadruplex landscapes through G-loop formation

Project description:RNA transcripts regulate G-quadruplex landscapes through G-loop formation

| PRJNA1120071 | ENA

RNA transcripts regulate G-quadruplex landscapes through G-loop formation (RNA-Seq)

Project description:RNA transcripts regulate G-quadruplex landscapes through G-loop formation (RNA-Seq)

| PRJNA1120076 | ENA

RNA transcripts regulate G-quadruplex landscapes through G-loop formation (RNA-Seq)

Project description:G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics is controlled remains poorly understood. Here, we report that RNA transcripts govern G4 landscapes through coordinated ‘G-loop’ assembly and disassembly. G-loop assembly involves activation of the ATM and ATR kinases followed by homology-directed invasion of RNA opposite the G4 strand mediated by BRCA2 and RAD51. Disassembly of the G-loop resolves the G4 structure via DHX36-FANCJ-mediated G4 unwinding that triggers nucleolytic incision and subsequent hybrid strand renewal by DNA synthesis. Inhibition of G-loop disassembly causes global G4 and R-loop accumulation, leading to transcriptome dysregulation, replication stress, and genome instability. These findings establish an intricate G-loop assembly-disassembly mechanism that controls G4 landscapes and is essential for cellular homeostasis and survival.

2025-04-02 | GSE269081 | GEO

RNA transcripts regulate G-quadruplex landscapes through G-loop formation

Project description:G-quadruplexes (G4s) are epigenetic DNA structures that regulate transcription but also threaten genome stability when dysregulated. It remains unknown how G4 dynamics is organized in a cell-specific manner. Here, we report that RNA transcripts govern G4 landscapes through homology-directed invasion opposite the G4 strand, forming ‘G-loops’. G-loops are disassembled via DHX36-FANCJ-mediated G4 unwinding and subsequent nucleolytic incision by XPF-ERCC1, leading to hybrid strand renewal through DNA synthesis. G-loop disassembly requires stochiometric invading RNAs, by contrast, excess of which stabilizes G-loops against disassembly. Defects in G-loop disassembly accumulate G-loops predominantly in gene regulatory regions, leading to transcriptional dysregulation, replication stress, and DNA damage throughout the cell cycle. These findings establish nuclear RNAs as pivotal G-loop regulators, linking the transcriptome to gene regulation and genome maintenance.

2025-06-20 | GSE268153 | GEO

RNA transcripts regulate G-quadruplex landscapes through G-loop formation (G4 and R-loop CUT&Tag)

Project description:RNA transcripts regulate G-quadruplex landscapes through G-loop formation (G4 and R-loop CUT&Tag)

| PRJNA1120075 | ENA

RNA transcripts regulate G-quadruplex landscapes through G-loop formation (G4 and R-loop CUT&Tag)

2025-04-02 | GSE269082 | GEO

RNA transcripts regulate G-quadruplex landscapes through G-loop formation

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-04-02 | GSE269084 | GEO

R-loop landscapes in Arabidopsis

Project description:R-loop landscapes in Arabidopsis

| PRJNA477830 | ENA

R-loop landscapes in yeast meiosis

Project description:R-loop landscapes in yeast meiosis

| PRJNA705491 | ENA

R-loop landscapes during parental-to-zygotic transition in zebrafish

Project description:The R-loop is a common chromatin feature presented from prokaryotic to eukaryotic genomes and has been revealed to be involved in multiple cellular processes. Here, we developed a novel R-loop profiling technique, ULI-ssDRIP-seq, to decte global R-loops from a limited number of cells. Based on this method, we profiled the R-loop landscapes during parental-to-zygotic transition and early development regulatory in zebrafish, and revealed a series of important characters of R-loops.

2024-05-29 | GSE183453 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data