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Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (main experiment)

ABSTRACT: Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (main experiment)

PROVIDER: PRJNA1126131 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29475200_1.fastq.gz	Fastqsanger.gz
	SRR29475200_2.fastq.gz	Fastqsanger.gz
	SRR29475201_1.fastq.gz	Fastqsanger.gz
	SRR29475201_2.fastq.gz	Fastqsanger.gz
	SRR29475202_1.fastq.gz	Fastqsanger.gz

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Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (main experiment)

Project description:Aging is associated with a number of physiologic changes including perturbed circadian rhythms; however, mechanisms by which rhythms are altered remain unknown. To test the idea that circulating factors mediate age-dependent changes in peripheral rhythms, we compared the ability of human serum from young and old individuals to synchronize circadian rhythms in culture.We collected blood from apparently healthy young (age 25-30) and old (age 70-76) individuals and used the serum to synchronize cultured fibroblasts. We found that young and old sera are equally competent at initiating robust ~24h oscillations of a luciferase reporter driven by clock gene promoter. However, cyclic gene expression is affected, such that young and old sera promote cycling of sets of different genes. Genes that lose rhythmicity with old serum entrainment are associated with oxidative phosphorylation and Alzheimer’s Disease as identified by STRING and IPA analyses. Also, the expression of cycling genes associated with cholesterol biosynthesis increased in the cells entrained with old serum. Genes involved in the cell cycle and transcription/translation remain rhythmic in both conditions, We did not observe a global difference in the distribution of phase between groups, but found that peak expression of several clock-controlled genes (PER3, NR1D1, NR1D2, CRY1, CRY2, and TEF) lagged in the cells synchronized ex vivo with old serum. Taken together, these findings demonstrate that age-dependent blood-borne factors affect peripheral circadian rhythms in cells and have the potential to impact health and disease via maintaining or disrupting rhythms respectively.

2024-06-26 | GSE270288 | GEO

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (preliminary experiment)

2024-06-26 | GSE270289 | GEO

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (preliminary experiment)

Project description:Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (preliminary experiment)

| PRJNA1126134 | ENA

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

Project description:Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

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Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

Project description:This SuperSeries is composed of the SubSeries listed below.

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Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms.

Project description: Not available

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Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms.

Project description: Not available

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"Cancersensor": Circadian Rhythms

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Project description:Plants adjust their growth in response to environmental cues by forming new organs in different development contexts. Underground lateral roots initiate from prepatterned cells in the main root, but cells can also bypass the root/shoot trajectory separation and generate shoot-borne-roots through an unknown mechanism. Here, we mapped tomato (Solanum lycoperiscum) shoot-borne-roots development at single-cell resolution and show that they initiate from differentiated phloem-associated cells via a unique transitional stem-cell-like state. This state required the activity of a transcription factor which we named SHOOTBORNE ROOTLESS (SBRL), a function that was deeply conserved in angiosperms. Phylogenetic analysis revealed that SBRL arose in angiosperms as an ancient duplicated superlocus with its paralogs showing root-type-specific transient expression in wound-induced and lateral root initiation. Mutants in all SBRL-like genes completely lost post-embryonic roots. We propose that the activation of a common transition state by context-specific regulators underlies the plasticity of plant root systems.

2022-03-04 | GSE159055 | GEO

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