RNA-seq of B7H3_CAR_T cells loaded with oncolytic virus VSVΔ51
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ABSTRACT:
PROVIDER: PRJNA1141895 | ENA |
REPOSITORIES: ENA
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Project description:RNA-seq of in vivo B7H3_CAR_T cells loaded with oncolytic virus VSVΔ51
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Project description:To investigate the in vivo functions of CR2/3-CAR-T loaded with VSVΔ51 after infiltrating tumor microenvironment, we analyzed the transcriptomic signatures at early stage after CAR-T infiltrating into tumor tissue. We isolated the CAR-T cells from the mouse tumor and used RNA sequence to study the global gene expression. We identified differentially expressed genes in B7H3-CAR-T cells and CR2/3-B7H3-CAR-T cells loaded with loading VSVΔ51, aiming to identify the changed pathways that are influenced by the cross-connection between VSV-G protein and CR2/3-CAR moiety.
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Project description:Interventions: Lung Cancer group:Novel Oncolytic Virus;Colorectal Cancer group:Novel Oncolytic Virus
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