Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: The first reported case of an intra-abdominal abscess caused by KPC-2-producing hypervirulent Klebsiella pneumoniae with porin mutations successfully treated with Imipenem/relebactam in a Japanese patient.

PROVIDER: PRJNA1168299 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR30870266_1.fastq.gz	Fastqsanger.gz
	SRR30870267_1.fastq.gz	Fastqsanger.gz
	SRR30870267_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Project description:Imipenem-relebactam resistance in KPC-producing Klebsiella pneumoniae

| PRJNA869900 | ENA

Project description:Resistance to imipenem-relebactam in KPC-producing Klebsiella pneumoniae

| PRJNA809903 | ENA

Project description:Induced resistance to imipenem-relebactam in KPC-producing Klebsiella pneumoniae

| PRJNA762266 | ENA

Pseudomonas aeruginosa

Project description:Imipenem and Imipenem/Relebactam susceptibility in Pseudomonas aeruginosa.

| PRJNA873916 | ENA

Project description:Imipenem/relebactam Challenge Set Genome sequencing and assembly

| PRJNA523732 | ENA

Genome sequencing and assembly of imipenem and imipenem-relebactam resistant clinical isolates of Pseudomonas aeruginosa

Project description:Genome sequencing and assembly of imipenem and imipenem-relebactam resistant clinical isolates of Pseudomonas aeruginosa

| PRJEB87800 | ENA

Project description:In vivo emergence of Imipenem/relebactam resistance in KPC-producing Klebsiella pneumoniae mediated by increased blaKPC copy number and porins

| PRJNA794363 | ENA

In vivo protein interaction network analysis reveals porin-localized toxin inactivation in antibiotic resistant bacteria

Project description:The nosocomial pathogen Acinetobacter baumannii is a frequent cause of hospital acquired infections worldwide, and a challenge for treatment due to its evolved resistance to antibiotics, including carbapenems. To gain insight on A. baumannii antibiotic resistance mechanisms, we analyzed the protein interaction network of a multidrug-resistant A. baumannii clinical strain Ab5075. Using in vivo chemical cross-linking and mass spectrometry, we identified 2,068 non-redundant cross-linked peptide pairs containing 245 intra- and 398 inter- molecular interactions. Outer membrane proteins OmpA and YiaD, and carbapenemase Oxa-23 are hubs of the identified interaction network. Eighteen novel interactors of Oxa-23 were identified. Interactions of Oxa-23 with outer membrane porins OmpA and CarO were verified with co-immunoprecipitation analysis. Furthermore, transposon mutagenesis of oxa-23 or interactors of Oxa-23 demonstrated changes in meropenem or imipenem sensitivity in Ab5075. These results provide the first view of a porin-localized toxin inactivation model and increase understanding of bacterial antibiotic resistance mechanisms.

2016-12-22 | PXD004236 | Pride

Project description:Multi-omic profiling for intra-abdominal hypertension

| PRJNA756796 | ENA

Project description:atypical hypervirulent Klebsiella pneumoniae that causes liver abscess and endocarditis

| PRJNA379106 | ENA