Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

FABP7 expression modulates the response of astrocyte to induced endotoxemia.

ABSTRACT: FABP7 expression modulates the response of astrocyte to induced endotoxemia.

PROVIDER: PRJNA1173601 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

FABP7 expression modulates the response of astrocyte to induced endotoxemia.

Project description:To investigate the effect of knocking down FABP7 expression in a mouse model of endotoxemia

2025-07-02 | GSE279612 | GEO

Astrocyte Fabp7 modulates seizure threshold and activity-dependent gene expression in mouse brain

Project description:Astrocyte Fabp7 modulates seizure threshold and activity-dependent gene expression in mouse brain

| PRJNA1134245 | ENA

FABP7 Expression Modulates the Response of Astrocytes to Induced Endotoxemia.

Project description: Not available

| S-EPMC12185976 | biostudies-literature

Astrocyte Fabp7 modulates seizure threshold and activity-dependent gene expression in mouse brain

Project description:Patients with epilepsy often experience increased frequency of seizures at night. Given the crucial role glial cells play in modulating neuronal excitability, we hypothesize that circadian changes in glia may affect changes in seizure threshold. Fatty acid binding protein 7 (Fabp7) is expressed in brain astrocytes and is involved in the transport of fatty acids, signal transduction, and gene transcription. Its mRNA expression levels rise and fall in a circadian rhythm and is necessary for normal sleep regulation. We examined if Fabp7 influences electrically induced seizure threshold and differential gene expression in wild type (WT) vs. Fabp7 knockout (KO) mice with and without seizure.

2024-11-06 | GSE271985 | GEO

Comprehensive transcriptome analysis of the cochleae of 7-month-old Fabp7 (+/+) and Fabp7 (-/-) mice

Project description:To discover the molecules and signal pathways that are associated with the anti-aging effects of Fabp7 deficiency, transcriptome analyses were conducted using DNA microarray. The ABR thresholds of Fabp7 (+/+) and Fabp7 (-/-) mice were not significantly different at 7 months of age, but it was speculated that important gene expression changes might arise at approximately this stage. Therefore, 7-month-old Fabp7 (+/+) and Fabp7 (-/-) mice were used for transcriptome analyses.

2017-06-23 | GSE83599 | GEO

FABP7 drives an inflammatory response in human astrocytes

Project description:To investigate the effect of FABP7 over-expression in human iPCS-derived astrocytes.

2024-02-07 | GSE214628 | GEO

Astrocyte FABP7 Modulates Seizure Activity-Dependent Protein Expression in Mouse Brain.

Project description: Not available

| S-EPMC12674186 | biostudies-literature

FABP7 controls radial glial scaffold stability during human cortical development

Project description:Radial glial (RG) cells serve as both neural progenitors and structural scaffolds for neuronal migration during cortical development. Although FABP7 has long been recognized as a marker of RG cells, its regulatory function has remained poorly defined. Using human fetal brain slices, embryonic mouse model, cerebral organoids, and assembloids, we demonstrate that FABP7 is essential for maintaining RG scaffold architecture and coordinating neuronal positioning. Single-cell analysis revealed that FABP7 deficiency induces transcriptional dysregulation, particularly affecting cytoskeletal organization, neural fate specification, and stress responses. Furthermore, Transcriptomic features in FABP7 knockdown organoids exhibit convergence with neurodevelopmental disorders such as autism, alongside recapitulation of scaffold defects observed in idiopathic autism organoids. Mechanistically, FABP7 loss suppresses the mevalonate (MVA) pathway, resulting in impaired GTPase-mediated cytoskeletal organization and disruption of radial scaffold integrity. These findings identify FABP7 as a key regulator of cortical development and disease-relevant molecular programs, linking metabolic signaling to neurodevelopmental vulnerability.

2026-03-28 | GSE304516 | GEO

FABP7 drives an inflammatory response in human astrocytes

Project description:FABP7 drives an inflammatory response in human astrocytes

| PRJNA886418 | ENA

The Wnt pathway inhibitor, LGK974 has suppressive effects for LPS-induced endotoxemia

Project description:We demonstrated that Wnt/β-catenin pathway was activated in in endotoxemic mice, and the modulation of this pathway by LGK974 had beneficial effects by suppressing the inflammation and lethality caused by endotoxemia.

2019-03-01 | GSE127459 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data