Project description:Numerous studies have demonstrated that golden pompano (Trachinotus blochii) is sensititive to hypoxia, which causes a devastating blow to the golden pompano industry. And different methods of reoxygenation after hypoxia could bring differnt effects on metabolism for golden pompano.
Project description:To investigate the functional role of LepR in golden hamsters, we performed RNA sequencing on LepR-knockout golden hamsters and their control group (wild-type golden hamsters). Further analysis revealed that LepR knockout led to the development of diabetic phenotypes in golden hamsters, with changes primarily driven by activation of inflammatory pathways, as well as dysregulation of lipid metabolism and the extracellular matrix. Thus, our study provides a novel animal model for the development of diabetes.
2026-09-02 | GSE327492 | GEO
Project description:Alexandrine parakeet gut microbiome
Project description:Emerging infectious diseases pose a significant threat to both human and animal populations. Rapid de novo identification of protective antigens from a clinical isolate and development of an antigen-matched vaccine is a golden strategy to prevent the spread of emerging novel pathogens. Here, we have developed a universal pipeline by integrating proteosurfaceomics, secretomics, and BacScan technologies for the rapid de novo identification of bacterial protective proteins from a clinical isolate without prior knowledge of the pathogenic bacterium. As a proof of concept, we identified 3 novel protective proteins of A. pleuropneumoniae. Using the protective protein HBS1_14 and toxin proteins, we have developed a promising multivalent subunit vaccine against A. pleuropneumoniae. We believe that our strategy can be applied to any bacterial pathogen and has the potential to significantly accelerate the development of antigen-matched vaccines to prevent the spread of an emerging novel bacterial pathogen.
