Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Biologically-inspired melt electrowriting for the generation of highly biomimetic functional myocardium

ABSTRACT: Biologically-inspired melt electrowriting for the generation of highly biomimetic functional myocardium

PROVIDER: PRJNA1182658 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31243041_1.fastq.gz	Fastqsanger.gz
	SRR31243041_2.fastq.gz	Fastqsanger.gz
	SRR31243042_1.fastq.gz	Fastqsanger.gz
	SRR31243042_2.fastq.gz	Fastqsanger.gz
	SRR31243043_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Biologically-inspired melt electrowriting for the generation of highly biomimetic functional myocardium

Project description:In the heart, the specific 3D structure of myocardial layers produces an efficient ejection of blood. When myocardial infarction strikes, this architecture is disrupted, adding a disarranged contraction to the decreased availability of pumping units (cardiomyocytes, CMs). In this work, we characterize the alignment of cardiac fibers in a large animal model (pig) and employ melt electrowriting (MEW) to fabricate a bio-inspired scaffold with diamond-shaped pores. Using human induced pluripotent stem cell-derived CMs and cardiac fibroblasts, we generate human cardiac tissues with a biomimetic in-plane contraction. Our tissues beat macroscopically for over one month, with significantly faster kinetics, increased force and higher conduction velocity than those based on square or rectangular pores. Our diamond design induces a specific hiPSC-CM alignment resulting in the observed in-plane contraction. Transcriptomic analysis using bulk RNA-seq reveals diamond-MEW tissues present features of maturation as compared to traditional 2D cultures. Finally, we employ the bio-inspired cardiac tissues to treat an infarction model in athymic rats, showing a significant benefit on systolic function and remodeling, tied to the presence of large grafts of human cells remuscularizing the ventricular wall. All in all, we demonstrate that the new design generates superior human cardiac tissues with therapeutic capacity.

2025-06-11 | GSE281166 | GEO

Oocyte-Inspired Universal Whole-Cell Vaccines Against Tumor Heterogeneity

Project description:Inspired by the zona pellucida, an extracellular armor that safeguards the oocyte, we engineered a biomimetic whole-tumor-cell vaccine whose mechanical properties can be precisely tuned while preserving the full spectrum of native tumor antigens.

2026-03-20 | PXD075990 |

Octopus-inspired triple-engineered bacteria for precision cancer immunotherapy

Project description:Bacterial cancer therapies face precision and safety challenges, which limit their clinical application. This study presents a triple-engineered Salmonella typhimurium strain (OITE-bacteria), designed for targeted cancer therapy, inspired by octopus biology and leveraging synthetic biology and biomimetic principles. The strain incorporates SpyTag proteins on the outer membrane, allowing covalent attachment of SpyCatcher-fused quadruple RGD peptides to enhance tumor adhesion via integrin αvβ3 interactions. This promotes bacterial enrichment in various solid tumors and lung metastases. Subsequently, Quorum sensing induces expression of strain HtrA protein within tumors, enhancing extracellular polysaccharide-mediated immunogenicity for activating immune cells. Additionally, the bacteria locally release anti-PD1 nanobodies to anti-immunosuppressive. In murine models, OITE-bacteria achieved a ninefold increase in tumor colonization within 12 hours and sustained melanoma growth suppression for over 40 days, with a 100% response rate. This modular approach, integrating safety and efficacy, provides a new strategy in microbial therapeutics for solid tumors.

2026-01-01 | GSE250146 | GEO

Biomimetic Virulomics

Project description:An affinity guided approach coupled with multiplexed quantitative proteomics, namely Biomimetic Virulomics, for successful identification of cell-type specific effector proteins of both prokaryotic and eukaryotic pathogens.

2017-02-15 | MSV000080551 | MassIVE

Differential expression of miRNA in ischemia-reperfusion myocardium

Project description:To detect the differential expression of miRNA in normal rat myocardium and ischemic hypoxic myocardium

2022-12-29 | GSE221780 | GEO

A biologically inspired network design model.

Project description: Not available

| S-EPMC4455180 | biostudies-literature

Modeling Phenotypic Heterogeneity Towards Evolutionary Inspired Osteosarcoma Therapy

Project description:Modeling Phenotypic Heterogeneity Towards Evolutionary Inspired Osteosarcoma Therapy

| PRJNA1003084 | ENA

Gene expression profile at single cell level for induction of human primordial germ cell-like cells (hPGCLCs) in a biomimetic culture

Project description:Transcriptome at the single-cell level of a biomimetic culture of primed human pluripotent stem cells (hPSCs) was profiled at Day 3 and Day 8. The biomimetic culture, which mimics the peri-implantation human epiblast development, provides an easily implementable culture protocol for deriving human primordial germ cell-like cells (hPGCLCs) from primed hPSCs .

2022-06-10 | GSE205611 | GEO

Biologically inspired crack trapping for enhanced adhesion.

Project description: Not available

| S-EPMC1904130 | biostudies-literature

Biologically Inspired Emotional Expressions for Artificial Agents.

Project description: Not available

| S-EPMC6053641 | biostudies-literature