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Assessing the contribution of RIPK1 in ZIKV-induced inflammatory transcription in neuorns

ABSTRACT: Assessing the contribution of RIPK1 in ZIKV-induced inflammatory transcription in neuorns

PROVIDER: PRJNA1182668 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31243200_1.fastq.gz	Fastqsanger.gz
	SRR31243200_2.fastq.gz	Fastqsanger.gz
	SRR31243201_1.fastq.gz	Fastqsanger.gz
	SRR31243201_2.fastq.gz	Fastqsanger.gz
	SRR31243202_1.fastq.gz	Fastqsanger.gz

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Assessing the contribution of RIPK1 in ZIKV-induced inflammatory transcription in neuorns

Project description:We previously have found that RIPK3 induces robust anti-viral and inflammatory transcriptional signaling in primary cortical neurons, however the complete molecular mechanism governing this pathway is incompletely understood. Here we show RIPK1 is required to induce RIPK3-dependent transcription in ZIKV-infected neurons.

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Assessing the role of RHIM proteins in ZIKV-induced inflammatory transcription in neurons

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Genome wide Affymetric Microarray analysis for RIPK1 dependent inflammatory changes in Bone Marrow Derived Macrophages (BMDMs)

Project description:Gene level expression estimate using the Whole Transcript (WT) Assay approach of the Gene 1.0 ST Array System for Mouse. This assay was done to identify the RIPK1-dependent gene expression changes in mouse BMDMs. Cost-effective gene-level analysis based on whole-transcript coverage. We analyzed Bone Marrow Derived Macrophages (BMDMs) under 4 different conditions (Control, LPS, LPS/zVAD, LPS/zVAD/Nec-1) to assess inflammatory changes in RIPK1 kinase dependent manner compared to LPS, LPS/zVAD plus RIPK1 inhibitor Nec-1 and control.

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