Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Comparative Toxicological Effects of Tire Wear and Latex Particle Leachates in Zebrafish Embryos: Focus on Oxidative Stress and Ferroptosis

PROVIDER: PRJNA1215813 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR32129951_1.fastq.gz	Fastqsanger.gz
	SRR32129951_2.fastq.gz	Fastqsanger.gz
	SRR32129952_1.fastq.gz	Fastqsanger.gz
	SRR32129952_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 17

Similar Datasets

Project description:Zebrafish larvae exposed by tire wear particles leachate and latex paticles leachate

| PRJNA1132896 | ENA

Tire-wear particle leachate toxicity to Americamysis bahia: analysis of sublethal and molecular effects

Project description:Tire-wear particles (TWPs) are considered among the largest contributors of microplastics to the environment. They are subject to break-down due to environmental weathering, which allows for potentially toxic chemicals to be leached from and sorbed onto the particles. In this study, leachate generated from “weathered” and “un-weathered” TWPs were used for sublethal toxicity tests with Americamysis bahia.

2025-01-01 | GSE223584 | GEO

Project description:Zebrafish larvae exposed by tire wear particles leachate and latex paticles leachate (long period, 30 days)

| PRJNA1215922 | ENA

Tire-wear particle leachate toxicity to Americamysis bahia: analysis of sublethal and molecular effects

Project description:Tire-wear particle leachate toxicity to Americamysis bahia: analysis of sublethal and molecular effects

| PRJNA926920 | ENA

Transcription profiling of human samples to identify markers for early diagnosis of of endoprosthesis loosening

Project description:The aim of the study was to identify markers for the early diagnosis of endoprosthesis loosening, for the differentiation between wear-particle induced and septic loosening, as well as to gather new insights into the pathogenesis. 824 genes were differentially expressed with a fold change greater than 2. Among these were Chitinase 1, CD52, Calpain 3, Apolipoprotein, CD18, Lysyl oxidase, Cathepsin D, E-Cadherin, VE-Cadherin, Nidogen, Angiopoietin 1 and Thrombospondin 2, and the differential expression levels were validated by RT-PCR. The chitinase activity was significantly higher in the blood from patients with wear-particle induced prosthesis loosening (p=0.001). However, using chitinase activity as a marker for early diagnosis, it has a specificity of 83% and a sensitivity of only 52%, due to a high variability both in the disease and in the control group. Experiment Overall Design: Gene expression profiles were generated from 5 periprosthetic membranes of wear-particle induced and 5 of infectious (septic) type using Affymetrix HG U133A oligonucleotide microarrays. The results of selected differentially expressed genes were validated by RT-PCR (n=30). The enzyme activity and the genotype of chitinase-1 were assessed in serum samples from 313 consecutive patients hospitalized for endoprosthesis loosening (n=54) or for other reasons, serving as control subjects (n=259).

2008-06-15 | E-GEOD-7103 | biostudies-arrayexpress

Project description:Zebrafish larvae exposed by tire wear particles leachate and latex paticles leachate (leaching for short-term period, 7 days)

| PRJNA1215929 | ENA

Project description:The effects of tire wear particles on zebrafish eyes

| PRJNA787741 | ENA

Data for identification of tire wear compound metabolites produced by the fungus Trametes Versicolor

Project description:This dataset contains results for a semi-untargeted metabolomics study on fungal metabolite identification of the tire wear compounds acetanilide and hexamethoxymethylmelamine. High-resolution Orbitrap mass spectrometry was used along with Compound Discoverer (version 3.1) for downstream analysis. Further information is available in the readme file and related publication.

2022-02-22 | MSV000088889 | MassIVE

Limited macrophage dynamics in progressing or regressing murine atherosclerotic plaques

Project description:Previous studies using particle labeled monocytes to assess recruitment into tissues have demonstrated that bead labeling did not affect the ability of monocytes to enter tissues (Tacke et al., 2007), and particle uptake did not activate p38/MAPK or NFκB pathways (Yates and Russell, 2005). However, the possibility remains that bead labeling could have effects on global gene expression profiles. To address this prospect, we performed gene expression profiling of classical and non-classical monocytes that had taken up latex particle in vivo against cells from the same mouse that had not taken up particles.

2018-07-13 | GSE117051 | GEO

Gene expression profiling in wear-particle induced and infectious endoprosthesis loosening

2008-01-01 | GSE7103 | GEO