Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Comparative Toxicological Effects of Tire Wear and Latex Particle Leachates in Zebrafish Embryos: Focus on Oxidative Stress and Ferroptosis

PROVIDER: PRJNA1215813 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR32129951_1.fastq.gz	Fastqsanger.gz
	SRR32129951_2.fastq.gz	Fastqsanger.gz
	SRR32129952_1.fastq.gz	Fastqsanger.gz
	SRR32129952_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 17

Similar Datasets

Transcriptomic Analysis of Zebrafish Larvae Exposed to Tire Wear Particle Leachates

Project description:Transcriptomic Analysis of Zebrafish Larvae Exposed to Tire Wear Particle Leachates

| PRJNA1273850 | ENA

Tire wear particle soil

Project description:Tire wear particle soil Raw sequence reads

| PRJNA1438814 | ENA

Tire wear particle soil Fungi

Project description:Tire wear particle soil Fungi Raw sequence reads

| PRJNA1438875 | ENA

Tire wear particle soil protists

Project description:Tire wear particle soil protists Raw sequence reads

| PRJNA1438900 | ENA

Developmental toxicity of tire wear particle (TWP) leachates produced in the presence or absence of simulated natural light

Project description:Developmental toxicity of tire wear particle (TWP) leachates produced in the presence or absence of simulated natural light

| PRJNA976478 | ENA

Project description:Zebrafish larvae exposed by tire wear particles leachate and latex paticles leachate

| PRJNA1132896 | ENA

Tire-wear particle leachate toxicity to Americamysis bahia: analysis of sublethal and molecular effects

Project description:Tire-wear particles (TWPs) are considered among the largest contributors of microplastics to the environment. They are subject to break-down due to environmental weathering, which allows for potentially toxic chemicals to be leached from and sorbed onto the particles. In this study, leachate generated from “weathered” and “un-weathered” TWPs were used for sublethal toxicity tests with Americamysis bahia.

2025-01-01 | GSE223584 | GEO

Project description:Zebrafish larvae exposed by tire wear particles leachate and latex paticles leachate (long period, 30 days)

| PRJNA1215922 | ENA

Project description:Microbial responses to tire wear particles

| PRJNA1451138 | ENA

Developmental toxicity of tire wear particle (TWP) leachates produced in the presence or absence of simulated natural light

Project description:Tire wear particles (TWP) are small micro- or nano-particles resulting from the friction of tire tread against roads. These microplastics have been found in waterways, usually through rain and wind, posing a potential risk to exposed aquatic life. The goal of this project was to assess the toxicity of chemical leachates from TWP and characterize how they may impact the health and development of aquatic life, like Danio rerio, zebrafish. Furthermore, we also determined if solar-simulated or dark conditions intensified the effects of TWP, considering processes like photodegradation and photochemical oxidation occur in sunlight. Zebrafish were exposed from 0-4 days post fertilization (dpf) to a filtered TWP solution at varying concentrations, and each concentration was leached in either solar-simulated or dark conditions. Mortality and hatching rates were quantified throughout the exposures, and physical anomalies were recorded at 4 dpf using microscopy. Ethyoxyresorufin-O-deethylase (EROD) activity, an indicator of Phase I biotransformation, was performed using fluorescent microscopt. RNA sequencing was performed for 4 dpf larvae. TWP exposures, regardless of leaching light status, increased mortality, yolk sac edema, pericardial edema, spinal curvature, and craniofacial malformations, while decreasing hatching and swim bladder inflation. Regardless of lighting during leaching, EROD activity increased in the liver and brain and decreased in the gut CYP1A. RNA sequencing revealed some conserved processes in response to TWP, regardless of light status during leaching, including those involved in neurobiological function. However, divergent responses were also observed for processes such as amino acid metabolism, steroid biosynthesis, and fatty acid metabolism. Overall, these results suggest a disruption of embryonic development in zebrafish when exposed to TWP, and that sunlight during chemical leaching can alter the molecular responses to TWP.

2025-08-25 | GSE233518 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data