Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The transcriptome sequencing of Galangin treated BGC823 Exosomes

ABSTRACT: The transcriptome sequencing of Galangin treated BGC823 Exosomes

PROVIDER: PRJNA1219580 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32240788.fastq.gz	Fastqsanger.gz
	SRR32240789.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

The transcriptome sequencing of Galangin treated BGC823 Exosomes

Project description:Galangin-containing exosomes (Galangin-Exo) were isolated from BGC823 cells treated with Galangin.RNA-seq technology was used to screen differentially expressed MicroRNAs (miRNAs) in Galangin-Exo. BGC823 cells can specifically take up Galangin-Exo. In addition, Galangin-Exo inhibited the growth of gastric cancer cells.

2025-04-23 | GSE288835 | GEO

Transcriptome profiling of osteoblasts treated with uMSC-derived exosomes

Project description:To investigate the function and affected pathways of uMSC-derived exosomes on ossification, we used human and rat osteoblast cell line hFOB1.19 and ROS1728 treated with either exosomes or exosome-free supernatent (which is the supernatent of exosome pelleting after ultracentrifugation) and a non-treated group as negative control. We take advantages of high through-put sequencing technology to fully reveal the transcriptome changes of the treated cells.

2023-03-01 | GSE113634 | GEO

Exosomal microRNA sequencing in Nicorandil pretreated and non-treated mesenchymal stem cell-derived exosomes

Project description:To investigate the specific miRNA conducting the cardioprotective effect of Nicorandil pretreated MSC-derived exosomes (MSCNIC-Exo) in cardiac repair, we performed microRNA sequencing on exosomes secreted from nicorandil pretreated MSCs and non-treated MSCs to identify differentially expressed miRNA.

2024-03-20 | GSE229889 | GEO

Exosomal microRNA sequencing in Tongxinluo pretreated and non-treated MSC-derived exosomes

Project description:In order to investigate the specific mechanisms underlying the cardioprotective effects of Tongxinluo pretreated MSC-derived exosomes (MSCTXL-Exo) in cardiac repair, we performed microRNA sequencing on exosomes secreted from Tongxinluo pretreated MSCs and non-treated MSCs to identify differentially expressed miRNA. We found that 18 miRNAs were identified to be upregulated and 25 miRNAs downregulated (over 2-fold change) in MSCTXL-Exo compared to MSC-Exo.

2022-06-01 | GSE184067 | GEO

Exosomal lncRNA sequencing in Atorvastatin treated and non-treated MSC-derived exosomes

Project description:In order to investigate the molecular mechanisms underlying the further enhancement of Atorvastatin pretreated MSC-derived exosomes (MSCATV-Exo) in cardiac protection, we performed lncRNA sequencing on exosomes secreted from ATV pretreated MSCs and non treated MSCs to identify differentially expressed lncRNA. We found that 450 lncRNAs were identified to be upregulated and 1332 lncRNAs downregulated (over 1.5 fold change) in MSCATV-Exo compared to MSC-Exo.

2019-02-28 | GSE113570 | GEO

Next generation sequencing showing miRNA profiles of exosomes derived from DHT-treated CAFs and matched ETOH-treated CAFs

Project description:Background: Androgen deprivation therapy (ADT) is the backbone of therapy for advanced prostate cancer (PCa). Despite the good initial response, castration resistance and metastatic progression will inevitably occur. Cancer-associated fibroblasts (CAFs) may be implicated in promoting metastasis of PCa after ADT. Our aim is to investigate the role and mechanism of CAF-derived exosomes involving in metastasis of PCa after ADT. Methods: PCa cells were co-cultured with exosomes derived from DHT-treated or ETOH-treated CAFs, and their migration and invasion differences under castration condition were examined both in vitro and in vivo. The miRNA profiles of exosomes derived from DHT-treated CAFs and matched ETOH-treated CAFs were analysed via next generation sequencing. The transfer of exosomal miR-146a-5p from CAFs to PCa cells was identified by fluorescent microscopy. The function and direct target gene of exosomal miR-146a-5p in PCa cells were confirmed through Transwell assays, luciferase reporter, and western blot. Findings: Compared with DHT-treated CAFs, exosomes derived from ETOH-treated CAFs dramatically increase migration and invasion of PCa cells under castration condition. MiR-146a-5p level in exosomes from ETOH-treated CAFs was significantly reduced. The loss of miR-146a-5p may strengthen the epithelial-mesenchymal transition (EMT) to accelerate cancer cells metastasis by modulating epidermal growth factor receptor (EGFR)/ERK pathway. Interpretation: CAFs-derived exosomal miR-146a-5p confers metastasis in PCa cells under ADT through the EGFR/ERK pathway and it may present a new treatment for PCa.

2022-08-02 | GSE154215 | GEO

Transcriptome profiling of osteoblasts treated with uMSC-derived exosomes

Project description:Transcriptome profiling of osteoblasts treated with uMSC-derived exosomes

| PRJNA453482 | ENA

Tumor macrophages treated with exosomes

Project description:Tumor macrophages treated with exosomes

| PRJNA841486 | ENA

The transcriptome sequencing of Chrysin treated Scc9 Extracellular vesicles

Project description:EVs-Chrysin(Chrysin-treated SCC9) were isolated from SCC9 cells that were treated with chrysin. To improve the therapeutic effect, AuNPs were carried by EVs-Chrysin (Au-EVs). Compared to BGC823 and HCC-LM3 cells, the uptake of Au-EVs were specific in SCC9 cells. Moreover, Au-EVs combined with NIR enhanced cell apoptosis in TSCC cells. To confirm the role of miRNAs in cell apoptosis, the differentially expressed miRNAs between EVs-Con and EVs-Chrysin were screened by RNA-seq.

2021-10-12 | GSE185562 | GEO

lncRNA expression alterations in mesothelial cells treated with exosomes

Project description:To investigate whether exosomes from ovarian cancer cell lines could change lncRNA expression in mesothelial cells, exosomes from ovarian cancer cells (SKOV3 cells, A2780 cells) were added to MeT-5A cells, PBS treatment was set as blank control. Total RNAs of MeT-5A cells treated with exosomes were extracted, and then lncRNA sequencing was performed.

2021-09-01 | GSE151233 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data