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Non-invasive characterization of human soft tissue sarcoma response to radiation therapy

ABSTRACT: Non-invasive characterization of human soft tissue sarcoma response to radiation therapy

PROVIDER: PRJNA1222002 | ENA |

REPOSITORIES: ENA

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Non-invasive characterization of human soft tissue sarcoma response to radiation therapy

Project description:Non-invasive characterization of human soft tissue sarcoma response to radiation therapy

| PRJNA1222003 | ENA

Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapy

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Project description:Alveolar soft-part sarcoma (ASPS) is an extremely rare, highly vascular soft tissue sarcoma affecting predominantly adolescents and young adults. In an attempt to gain insight into the pathobiology of this enigmatic tumor, we performed the first genome-wide gene expression profiling study.

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In Vitro Characterization of MHH-ES-1 Preclinical Radiation-Adapted Model for Ewing Sarcoma

Project description:Analysis of differentially expressed genes in wild type MHH-ES-1 Ewing Sarcoma cells when compared to MHH-ES-1 Ewing Sarcoma cells that received six 4 Gy fractions (cumulative dose of 24 Gy) of ionizing radiation (radiation-adapted cell line). The hypothesis tested being that repeated ionizing radiation exposure of modifies radiation therapy response in Ewing Sarcoma.

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Project description:The heterogeneity and multiple histological categories of soft tissue sarcoma (STS) underlie a need for better classification schemes to improve their management. As none are currently available, we aimed to derive hypoxia and intrinsic molecular subtype mRNA abundance signatures for localized soft tissue sarcoma. RNA sequencing was used to identify genes induced by hypoxia in seven STS cell lines.

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