Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genetic Analysis of Variation in Transcription Factor Binding in Yeast

ABSTRACT: Genetic Analysis of Variation in Transcription Factor Binding in Yeast

PROVIDER: PRJNA122523 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize

Project description:Comprehensive maps of functional variation at transcription factor (TF) binding sites (cis-elements) are crucial for elucidating how genotype shapes phenotype. Here, we report the construction of a pan-cistrome of the maize leaf under well-watered and drought conditions. We quantified haplotype-specific TF footprints across a pan-genome of 25 maize hybrids and mapped over two hundred thousand (epi)genetic variants (termed binding-QTL) linked to cis-element occupancy. Three lines of evidence support the functional significance of binding-QTL: i) coincidence with causative loci that regulate traits, including VGT1, ZmTRE1, and the MITE transposon near ZmNAC111 under drought; ii) bQTL allelic bias is shared between inbred parents and matches ChIP-seq results, iii) partitioning genetic variation across genomic regions demonstrates that binding-QTL capture the majority of heritable trait variation across ~72% of 143 phenotypes. Our study provides an auspicious approach to make functional cis-variation accessible at scale for genetic studies and targeted engineering of complex traits.

2025-04-16 | GSE294039 | GEO

Divergence of Transcription Factor Binding Sites in Related Yeast Species

Project description:Divergence of Transcription Factor Binding Sites in Related Yeast Species

| PRJNA96077 | ENA

Genetic analysis of variation in transcription factor binding in yeast.

Project description: Not available

| S-EPMC2941147 | biostudies-literature

Rare genetic variation at transcription factor binding site modulates local DNA methylation profiles

Project description:Rare genetic variation at transcription factor binding site modulates local DNA methylation profiles

| PRJNA670916 | ENA

Natural genetic variation in yeast longevity

Project description:A quantitative genetic analysis of the yeast replicative life span was carried out by sampling the natural genetic variation

2012-07-18 | GSE37590 | GEO

Survey of transcription factor binding sites in yeast using ChIP-seq

Project description:Survey of transcription factor binding sites in yeast using ChIP-seq

| PRJEB2327 | ENA

Genetic Analysis of Variation in Transcription Factor Binding in Yeast

Project description:This SuperSeries is composed of the SubSeries listed below.

2010-02-18 | GSE19636 | GEO

Transcription factor binding divergence across maize inbred lines drives transcriptional and phenotypic variation

Project description:Transcription factor binding divergence across maize inbred lines drives transcriptional and phenotypic variation

| PRJNA1153532 | ENA

Natural genetic variation in yeast longevity

Project description:A quantitative genetic analysis of the yeast replicative life span was carried out by sampling the natural genetic variation Genomic DNA was extracted from 39 recombinant lines from a cross between strains S96 and YJM 789.

2012-07-17 | E-GEOD-37590 | biostudies-arrayexpress

ChIP-Seq of yeast to survey transcription factor binding sites

Project description:An experiment was performed to determine the transcription factor binding site of yeast at room temperature.

2011-10-13 | E-MTAB-440 | biostudies-arrayexpress