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PbAP2-TR plays a role in regulating major transcriptomic changes from early to late trophozoite [PbAP2-TR_ChIP-seq]

ABSTRACT: PbAP2-TR plays a role in regulating major transcriptomic changes from early to late trophozoite [PbAP2-TR_ChIP-seq]

PROVIDER: PRJNA1228589 | ENA |

REPOSITORIES: ENA

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PbAP2-TR plays a role in regulating major transcriptomic changes from early to late trophozoite [PbAP2-TR_RNA-seq]

Project description:Plasmodium berghei transcriptomes of pbap2-tr-DiCre, a parasite line in which pbap2-tr is disrupted by DiCre-mediated recombination in the presence of rapamycin, were analyzed at the trophozoite stage.

2025-07-01 | GSE290545 | GEO

PbAP2-TR plays a role in regulating major transcriptomic changes from early to late trophozoite [PbAP2-TR_ChIP-seq]

Project description:To investigate the genome-wide binding sites of PbAP2-TR and PbMORC in the asexual blood stage of Plasmodium berghei, the chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) analyses were performed. Parasites expressing GFP-fused PbAP2-TR or GFP-fused PbMORC were generated from the Cas9-expressing parasite (PbCas9), and pbap2-g was disrupted in these parasites (PbAP2-TR::GFPpbap2-g(-) and PbMORC::GFPpbap2-g(-)). Whole blood was harvested from mice infected with these transgenic parasites at 12 h post infection,and the parasites were then subjected to ChIP-seq experiments using anti-GFP antibody. Genome-wide binding sites of PbAP2-TR were determined from the sequence data.

2025-07-01 | GSE290542 | GEO

PbAP2-TR plays a role in regulating major transcriptomic changes from early to late trophozoite [pbap2-g_KO_RNA-seq]

Project description:Plasmodium berghei transcriptomes of gametocyte-absent mutant parasites, the pbap2-g-knockout line (pbap2-g(-)), were analyzed from ring to trophozoite stages by high-throughput RNA sequencing (RNA-seq) analysis.

2025-07-01 | GSE290541 | GEO

PbAP2-TR plays a role in regulating major transcriptomic changes from early to late trophozoite [PbAP2-TR_DIP-seq]

Project description:PbAP2-TR plays a role in regulating major transcriptomic changes from early to late trophozoite [PbAP2-TR_DIP-seq]

| PRJNA1228587 | ENA

PbAP2-TR plays a role in regulating major transcriptomic changes from early to late trophozoite [pbap2-g_KO_RNA-seq]

Project description:PbAP2-TR plays a role in regulating major transcriptomic changes from early to late trophozoite [pbap2-g_KO_RNA-seq]

| PRJNA1228596 | ENA

PbAP2-TR plays a role in regulating major transcriptomic changes from early to late trophozoite [PbAP2-TR_RNA-seq]

Project description:PbAP2-TR plays a role in regulating major transcriptomic changes from early to late trophozoite [PbAP2-TR_RNA-seq]

| PRJNA1228597 | ENA

PbAP2-TR plays a role in regulating major transcriptomic changes from early to late trophozoite [PbAP2-TR_DIP-seq]

Project description:To investigate the DNA-binding property of AP2 domains of PbAP2-TR, DNA immunoprecipitation followed by high-throughput sequencing (DIP-seq) analysis was performed. Recombinant AP2 domains 1–2 or AP2 domain 3 fused with maltose-binding protein (MBP) were mixed with the P. berghei genomic DNA fragmented via sonication, and protein-DNA complex was harvested using amylose resin. The obtained DNA fragments were sequenced via the next generation sequencing.

2025-07-01 | GSE290544 | GEO

Clostridioides mangenotii TR strain:TR

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PbAP2-FG2 and AP2R-2 function together as a transcriptional repressor complex essential for Plasmodium female development [RNA-seq]

Project description:Plasmodium berghei transcriptomes of pbap2-fg2 and ap2r-2 knockout parasites [pbap2-fg2(-) and ap2r-2(-), respectively] were analyzed at the gametocyte stage.

2023-02-02 | GSE213773 | GEO

PbAP2-FG2 and AP2R-2 function together as a transcriptional repressor complex essential for Plasmodium female development [ChIP-seq]

Project description:To investigate the genome-wide binding sites of the transcriptional regulators, PbAP2-FG2 and AP2R-2 in female gametocytes of Plasmodium berghei, the chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) analyses were performed. Parasites expressing GFP-fused PbAP2-FG2 (PbAP2-FG2::GFP) or GFP-fused AP2R-2 (AP2R-2::GFP) were harvested after treating the infected mice with sulfadiazine and subjected to ChIP-seq experiments using anti-GFP antibody. Binding sites of PbAP2-FG2 and AP2R-2 were determined from the sequence data.

2023-02-02 | GSE213775 | GEO

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