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Characterization of chicken peripheral blood mononuclear cells (PBMCs) during AIV prime vaccinations at single-cell resolution

ABSTRACT: Characterization of chicken peripheral blood mononuclear cells (PBMCs) during AIV prime vaccinations at single-cell resolution

PROVIDER: PRJNA1233248 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR22822933_1.fastq.gz	Fastqsanger.gz
	SRR22822933_2.fastq.gz	Fastqsanger.gz
	SRR22822934_1.fastq.gz	Fastqsanger.gz
	SRR22822934_2.fastq.gz	Fastqsanger.gz
	SRR22880846_1.fastq.gz	Fastqsanger.gz

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Characterization of chicken peripheral blood mononuclear cells (PBMCs) during AIV prime vaccinations at single-cell resolution

Project description:We performed scRNA-seq for PBMCs isolated from 35-day old healthy male SPF chicken at the onset or upon vaccination with live-attenuated or inactivated AIV vaccines.

2025-05-29 | GSE291364 | GEO

Characterization of chicken peripheral blood mononuclear cells (PBMCs) during prime vaccinations at single-cell resolution

Project description:Characterization of chicken peripheral blood mononuclear cells (PBMCs) during prime vaccinations at single-cell resolution

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Characterization of chicken peripheral blood mononuclear cells (PBMCs) during prime vaccinations at single-cell resolution

Project description:We performed scRNA-seq for PBMCs isolated from 35-day-old healthy male SPF chicken at the onset or upon vaccination with live-attenuated or inactivated IBV vaccines.

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Project description:Genome-Scale draft model for Human Peripheral Blood Mononuclear Cells (PBMCs). A GEM for PBMCs was developed by applying the INIT algorithm on Human Metabolic Reconstruction (HMR 2.0) as a template model. GEMs were contextualised/ constrained for different conditions using expression datasets. The gene/transcript expression data obtained from PBMCs of Type 1 Diabetes progressors, non-progressors, and healthy controls were employed to score each reaction of HMR 2.0. For further detail please refer to Electronic Supplementary Information of Sen et.al, Metabolic alterations in immune cells associate with progression to type 1 diabetes, Diabetologia, 15/01/2020, (https://doi.org/10.1007/s00125-020-05107-6).

2020-03-11 | MODEL1905270001 | BioModels

Goat Peripheral Blood Mononuclear Cells (PBMCs) responses to infection vary with Peste des Petits Ruminants Virus virulence

Project description:Peste des Petits Ruminants (PPR) is a highly infectious disease caused by a virus of the genus Morbillivirus (PPRV), infecting mainly sheep and goat. Susceptibility of host can vary widely with host breed and virus strain. The mechanisms underlying this variability are not well understood. Here, we carried out the first comparative in vitro study on goat peripheral blood mononuclear cells (PBMCs) infected with PPRV strains of different virulence, vaccine strain (N75/1), low- (IC89), and high-virulent strain (MA08). Goat PBMCs were infected by the different strains and stimulated with Concanavalin A (Con A), and proteome changes of these cells were evaluated during the infection. The level of PPRV replication was assessed first by RT-qPCR quantification of viral N mRNA and by labelling the viral N protein inside the cells with specific antibodies and analysed by flow cytometry. The dynamics of PBMC sub-populations were also evaluated by flow cytometry. Our results showed that viral replication is critical for PPRV inhibitory effect on PBMCs proliferation. Highly virulent MA08 strain reached a higher level of replication in ConA-stimulated PBMCs and induced higher mortality compared to other strains. Low-virulent IC89 strain showed the lower replication level and cell proliferative inhibitory capacities. Differences in immune genes expression levels were assessed using RNAseq analysis and protein expression was compared using mass spectrometry. Analysis of these data provided the transcriptional and proteome landscape of PBMCs infected with these strains. The possible association between the transcriptional and proteome landscape and changes in immune cell subpopulations dynamics was explored.

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Project description:The knowledge of circRNAs in tuberculosis (TB) remains limited. Aim of the present study was to characterize the expression profiles and potential function of circRNAs in human peripheral blood mononuclear cells (PBMCs) from patients with active TB.

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Project description:Whole transcriptome analysis of EBV infected peripheral blood mononuclear cells (PBMCs)

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