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Single nucleus RNA-seq of subcortical white matter from lysophosphatidylcholine (LPC) and cuprizone toxicity mouse models

ABSTRACT: Single nucleus RNA-seq of subcortical white matter from lysophosphatidylcholine (LPC) and cuprizone toxicity mouse models

PROVIDER: PRJNA1246592 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR32982384.fastq.gz	Fastqsanger.gz
	SRR32982385.fastq.gz	Fastqsanger.gz
	SRR32982386.fastq.gz	Fastqsanger.gz
	SRR32982387.fastq.gz	Fastqsanger.gz
	SRR32982388.fastq.gz	Fastqsanger.gz

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Single nucleus RNA-seq of subcortical white matter from lysophosphatidylcholine (LPC) and cuprizone toxicity mouse models

Project description:We compared the transcriptional changes in the cells of the corpus callosum, focusing on the oligodendrocyte and microglia, between LPC and cuprizone mediate demyelination. We further compared the transcriptional phenotypes to human MS patient samples. We identified distinct disease-associated oligodendrocyte states with shared pathological changes to MS, and observed a common but altered remyelination state between the models. Microglia response to demyelination is highly conserved, but human MS-associated microglia exhibit significantly more heterogeneity than we found in the mouse models. (doi: https://doi.org/10.1101/2025.03.24.645058)

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