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Expression data from macrophages sorted from Human Aortic Smooth Muscle Cells treated by PM2.5

ABSTRACT: Expression data from macrophages sorted from Human Aortic Smooth Muscle Cells treated by PM2.5

PROVIDER: PRJNA1251504 | ENA |

REPOSITORIES: ENA

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Expression data from macrophages sorted from Human Aortic Smooth Muscle Cells treated by PM2.5

Project description:Transcriptomic analysis implicated that PM2.5 could influence genes involved in the IRE1α-mediated unfolded protein responses and reduce the expression of DNAJB9, a co-chaperone formed a complex with BiP/IRE1α to inhibit the activation of endoplasmic reticulum (ER) stress. We investigate the mRNA expression of Human Aortic Smooth Muscle Cells induced by PM2.5 exposure by microarray.

2025-04-21 | GSE294723 | GEO

Transcriptome accessment of human aortic smooth muscle cell and rat aortic smooth muscle cell [HASMC_RASMC_RNASeq]

Project description:We report the transcriptome within human aortic smooth muscle cell and rat aortic smooth muscle cell. Some of the cells were treated with cholesterol.

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Smooth muscle cell reprogramming in aortic aneurysms [RNA-Seq]

Project description:Smooth muscle cell TGFβ signaling is one of the primary drivers of smooth muscle cell maturation. Inhibition of smooth muscle cell TGFβ signaling in hyperlipidemic mice induces vessel wall inflammation and vessel wall dilation/dissection and leads aortic aneurysm. We performed bulk RNAseq method to examine smooth muscle cell gene expression profile using fresh human tissues from normal aortic media smooth muscle cells and aneurysm aortic media smooth muscle cells.

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Chromatin accessibility in human aortic smooth muscle cells

Project description:We report the chromatin accessibilty profile within human aortic smooth cells

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Transcriptome accessment of human aortic smooth muscle cell and rat aortic smooth muscle cell [HASMC_RASMC_RNASeq]

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Smooth muscle cell reprogramming in aortic aneurysms [scRNA-Seq]

Project description:Smooth muscle cell TGFβ signaling is one of the primary drivers of smooth muscle cell maturation. Inhibition of smooth muscle cell TGFβ signaling in hyperlipidemic mice induces vessel wall inflammation and vessel wall dilation/dissection and leads aortic aneurysm. We performed scRNAseq method to examine smooth muscle cell gene expression profile using Apoe and SMC specific TGFbR2 KO in Apoe background mice.

2020-03-01 | GSE141031 | GEO

Smooth muscle cell reprogramming in aortic aneurysms

Project description:Smooth muscle cell reprogramming in aortic aneurysms

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Smooth muscle cell-specific Klf4 deletion in Marfan syndrome aortic root aneurysm

Project description:Aortic smooth muscle cell (SMC) phenotype modulation is a central feature of cell-mediated pathology in Marfan syndrome aortic aneurysm and Klf4 is proposed to contribute to this process. We generated mice with smooth muscle cell-specific Klf4 deletion using an Myh11-creERT2 transgene, induced deletion at 8 weeks and performed single cell RNA sequencing at 24 weeks on whole aortic root tissues.

2022-08-23 | GSE206227 | GEO

Aortic smooth muscle cells in bicuspid valve patients

Project description:and with higher incidence if associated to bicuspid aortic valve (BAV) for unknown reasons. TAA is usually diagnosed fortuitously and the lack of effective drug therapy to delay progression and avoid dissection lies in the limited knowledge of pathophysiology. Objectives. We aimed to identify the molecular hallmarks that difference the aortic dilatation associated to bicuspid (BAV) and tricuspid aortic valve (TAV) patients while setting plasma diagnostic molecular panels valve-associated. Methods. Sporadic TAA patients and control subjects (n=91) were classified according to valve type (BAV, TAV). Vascular smooth muscle cells isolated from TAA patients’ aortas were firstly analyzed by mass spectrometry based high-throughput proteomics according to valve type. Extracellularly secreted proteins were secondly analyzed in plasma from TAA patients versus control subjects as diagnostic candidates. Results. Aneurysmal aortas from BAV patients showed a stress phenotype, weakened extracellular matrix interactions, DNA damage and affected protein homeostasis compared to TAV patients. Two plasma marker panels of sporadic TAA valveassociated were identified, showing significant correlation with aortic diameter for C1QTNF5, LAMA2, and SPARC proteins, in BAV patients, and for CP and FAP proteins, in TAV patients. Conclusions. The arterial wall of BAV patients shows a limited capacity to counteract drivers of sporadic TAA while resembling aged arteries.The molecular pathways identified here support the need of differential molecular diagnosis and therapeutic approaches for BAV and TAV patients.

2024-10-17 | PXD043062 | Pride

Expression anaysis of mouse aortic vascular smooth muscle cells

Project description:Analysis of differential gene expression of aortic vascular smooth muscle cells isolated from Tie2floxed:SM22α Cre- (WT) and Tie2floxed:SM22α Cre+ (KO) mice Looking for candidates, that could potentialy be upregulated or downregulated

2017-06-23 | GSE100364 | GEO

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