Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dissection of the immune landscape in Psoriatic Arthritis patients [Mouse scRNA-seq]

ABSTRACT: Dissection of the immune landscape in Psoriatic Arthritis patients [Mouse scRNA-seq]

PROVIDER: PRJNA1253673 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Dissection of the immune landscape in Psoriatic Arthritis patients

Project description:Dissection of the immune landscape in Psoriatic Arthritis patients

| PRJNA1162877 | ENA

Dissection of the immune landscape in Psoriatic Arthritis patients [Mouse scRNA-seq]

Project description:Despite significant advancements in psoriatic arthritis (PsA) treatment modalities, a considerable proportion of patients continue to experience persistent joint inflammation and functional impairment, unresponsive to the armamentarium of biological disease-modifying antirheumatic drugs (bDMARDs) or Janus kinase (JAK) inhibitors. The etiology of resistance in these cases is complex, likely involving intricate immunological and genetic factors which are currently mostly unknown. Identifying novel biomarkers and targets for refractory disease is urgently needed. Here, utilizing single-cell RNA-sequencing of synovial fluid from 41 PsA patients and 9 Osteoarthritis (OA) controls we map the comprehensive immune landscape of PsA. Our analysis reveals major perturbations within the myeloid compartment, identifying distinct cell subsets and altered gene programs in PsA patients. Notably, within the myeloid compartment, refractory patients exhibit elevated expression of interferon- gamma induced gene programs linked to the immunoproteasome and MHC class I antigen presentation, at both the gene and protein level. These results suggest a potential interaction of the immunoproteasome and MHC class I antigen presentation in refractory PsA patients with sustained inflammation. Our research imparts critical insights into PsA pathogenesis, paving the way for both molecular level patient classification and potentially new therapeutic interventions for currently treatment resistant patients.

2025-07-23 | GSE295180 | GEO

Proteinases in psoriatic arthritis

Project description:Characterize active synovial fluid (SF) serine proteinases in psoriatic arthritis (PsA) in comparison to osteoarthritis (OA) and rheumatoid arthritis (RA)

2021-03-29 | PXD022442 | Pride

Dissection of the immune landscape in Psoriatic Arthritis patients

2025-06-12 | GSE277596 | GEO

Psoriatic arthritis

Project description:This is a pilot single cell mRNA sequencing experiment to study immune cells in psoriatic arthritis.

| EGAS00001002104 | EGA

Psoriatic arthritis WGS

Project description:Whole genome sequencing of immune cells from patients diagnosed with psoriatic arthritis

| EGAS00001002822 | EGA

Changes in neutrophil gene expression in psoriatic arthritis patients in response to sekukinumab

Project description:We report changes in gene expression in human peripheral blood neutrophils from patients with psoriatic arthritis (PsA) before and 12-weeks after treatment with Secukinumab (SKB, 150mg). All patients achieved a good PSARC (Psoriatic Arthritis Response Criteria) and PASI 90 (Psoriasis Area and Severity Index) response to treatment. We also report gene expression in healthy control neutrophils compared to patients wth psoriatic arthritis.

2023-01-06 | GSE179800 | GEO

Epigenomic analysis of sperm cells from patients with psoriatic arthritis, psoriasis without arthritis, and healthy controls

Project description:Genome-wide DNA methylation profiling of motile spermatozoa from 23 patients with psoriasis without arthritis, 13 psoriatic arthritis, and 18 unaffected controls using the Infinium HumanMethylation 450k v1 platform.

2019-02-02 | GSE126017 | GEO

Characterisation of peripheral blood mononuclear cell microRNA in Early Onset Psoriatic Arthritis

Project description:The expression of 723 mature miRNAs in peripheral blood mononuclear cells of patients with early, active psoriatic arthritis ,early-rheumatoid arthritis (ERA) (both groups treatment naïve) and of healthy controls (HC) was analysed using a miRNA microarray.

2016-12-01 | E-MTAB-3956 | biostudies-arrayexpress

Identifying Serum Metabolomic Markers Associated with Skin Disease Activity in patients with Psoriatic Arthritis

Project description:This dataset contains .RAW files acquired for the paper: Identifying Serum Metabolomic Markers Associated with Skin Disease Activity in patients with Psoriatic Arthritis.

| MSV000092967 | MassIVE

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data