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Transcriptomic profiling of primary human dermal fibroblasts treated with BoNTA

ABSTRACT: Transcriptomic profiling of primary human dermal fibroblasts treated with BoNTA

PROVIDER: PRJNA1254132 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR33250194_1.fastq.gz	Fastqsanger.gz
	SRR33250194_2.fastq.gz	Fastqsanger.gz
	SRR33250195_1.fastq.gz	Fastqsanger.gz
	SRR33250195_2.fastq.gz	Fastqsanger.gz

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Transcriptomic profiling of primary human dermal fibroblasts treated with BoNTA

Project description:This study aimed to explore the transcriptomic changes in primary human dermal fibroblasts upon treatment with Botulinum toxin type A (BoNTA). BoNTA is a neurotoxin known for its clinical use in dermatology, and emerging evidence suggests potential antifibrotic and anti-inflammatory effects at the cellular level. We performed high-throughput RNA sequencing to assess the global gene expression profiles in fibroblasts treated with BoNTA (1 U/ml) for 24 hours, compared with vehicle control (PBS). This dataset provides valuable insights into the molecular mechanisms of BoNTA in skin-resident fibroblasts and offers a reference for future investigations into its therapeutic roles in fibrotic skin diseases.

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Project description:Primary human dermal fibroblasts were isolated from an individual showing a genetic defect in innate antiviral immunity associated with profound failure of type 1 interferon signaling and absence of the STAT2 protein. The transcriptional response of these cells to a 10h treatment with interferon-alpha was compared with that of control dermal fibroblasts. We used microarrays to detail the global program of gene expression resulting from interferon-alpha treatment in STAT 2 deficient and control fibroblasts. Primary human dermal fibroblasts were grown in the presence or absence of 1,000U/ml interferon-alpha (IFNa) for 10 hours before RNA extraction and hybridization on Affymetrix microarrays.

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