Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ScRNA-seq of Lecanamab- and IgG1-treated xenotrasplanted human microglia

ABSTRACT: scRNA-seq of Lecanamab- and IgG1-treated xenotrasplanted human microglia

PROVIDER: PRJNA1265652 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

scRNA-seq of Lecanamab- and IgG1-treated xenotrasplanted human microglia

Project description:We investigated the transcriptomic changes of human microglia xenotransplanted in a mouse model of AD upon treatment with Lecanamab (Lec) compared to control (IgG1). Single-cell RNA sequencing reveals that Lec treatment induces a transcriptional program in microglia that promotes amyloid plaque removal, involving pathways related to phagocytosis, metabolism, antigen presentation, unfolded protein response, and interferon response.

2025-07-31 | GSE297665 | GEO

Expression data from cell lines treated with enavatuzumab and human IgG1 control

2013-10-31 | GSE51934 | GEO

Nova-ST spatial transcriptomics of Lecanamab- and Lecanemab LALA-PG-treated xenotrasplanted human microglia [ST]

Project description:We investigated the effect of Lecanemab's Fc effector function on the transcriptomes of human microglia xenotransplanted in a mouse model of AD. We performed Nova-ST spatial transcriptomics analysis on xenografted mice treated with Lecanemab and Lecanemab LALA-PG, a human IgG1 variant designed to abolish Fc-mediated effector functions. We found that treatment with Lecanemab induced phagocytic and lysosomal reprogramming in the microglia surrounding plaques, an effect that was not present upon Lecanemab LALA-PG.

2025-07-31 | GSE297667 | GEO

Expression data from liver of Recombinant human IgG1 treated high-fat-diet-induced ApoE-/- mice

Project description:On the basis of the clear role of Recombinant human IgG1 in the reduction of liver triglyceride (TG) level elevated by high-fat-diet, the potential effector genes of Recombinant human IgG1 are screened by means of transcriptional techniques.

2022-12-12 | GSE190421 | GEO

Expression data from cell lines treated with enavatuzumab and human IgG1 control

Project description:Cancer lines were treated with enavatuzumab and a human IgG1 control (MSL109) in vitro. Samples were extracted at various time points and analyzed via genechip. We used microarrays to examine gene expression patterns following treatment with enavatuzamab. Expression changes over time were compared with corresponding data from samples treated with a control. 16 samples were analyzed for each cell line, with duplicate samples at 4 different time points (from 6 hours to 3 days) for each of the 2 treatments (enavatuzumab and control).

2013-10-31 | E-GEOD-51934 | biostudies-arrayexpress

RNAseq Iron-Treated iPSC-derived Microglia

Project description:Iron accumulation in microglia has been observed in AlzheimerÃ¢Â€Â™s disease and other neurodegenerative disorders and is thought to contribute to disease progression through various mechanisms including neuroinflammation. To study the interaction between iron accumulation and inflammation, we treated human induced pluripotent stem cell-derived microglia (iPSC-MG) with an increasing concentration of iron, in combination with inflammatory stimuli such as interferon gamma and amyloid ÃŽÂ², and performed RNA sequencing.

| EGAS00001006112 | EGA

In vitro human H9 ESC-derived microglia scRNA seq

Project description:In vitro human H9 ESC-derived microglia scRNA seq

| PRJNA1027828 | ENA

Differential gene expression of human natural killer cells following immobilized IgG1 stimulation

Project description:Analysis of human natural killer cells following stimulation with immobilized IgG1 for 4 and 24 hours. Results identified significantly differentially expressed genes in natural killer cells stimulated with immobilized IgG1 providing insight into how antibodies modulate the transcriptome in way that may contribute to cell activation and immune tolerance

2019-01-24 | GSE109573 | GEO

Transcriptomics of BCR-stimulated IgG1 and IgG4 human B cell clones

Project description:We characterize the transcriptomic profile of a set of human IgG1 and IgG4-switched memory B cell clones

2020-05-26 | GSE129616 | GEO

Transcriptomic and functional deficits in human TREM2-/- microglia impair response to Alzheimer's pathology in vivo [scRNA-seq]

Project description:scRNA-sequencing of human xenotransplanted microglia isogenic for TREM2 after exposure to amyloid pathology

2020-09-19 | GSE158234 | GEO