Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1266368 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR33662525_1.fastq.gz | Fastqsanger.gz | |||
| SRR33662525_2.fastq.gz | Fastqsanger.gz |
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Project description:Tilapia Lake Virus (TiLV) poses a significant threat to global tilapia aquaculture, causing high mortality rates and severe economic losses. Despite its impact, the molecular mechanisms of TiLV-host interactions remain poorly understood. This study investigates the proteomic and phosphoproteomic changes in two piscine cell lines, E-11 and RHTiB, following TiLV infection.
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Project description:Oreochromis niloticus represents a critically important species in the aquaculture industry due to its economic significance. Probiotics used as feed additives are known to enhance the growth performance and health of tilapia. However, the underlying mechanisms by which these benefits are conferred remain poorly understood. Here, we demonstrate that Lactobacillus salivarius exhibits significant growth performance-enhancing effects when used as a feed additive. Utilizing multi-omics approaches, our results revealed that L. salivarius significantly modulates the composition and abundance of the intestinal microbiota. Bile acids, choline, and tryptophan were identified as pivotal factors in the microbial-mediated modulation of systemic metabolism. Additionally, we have delineated a single-cell atlas of the tilapia intestine for the first time, discovering that L. salivarius_01 increases the populations of intestinal epithelial cells, immune cells, and epithelial stem cells. A broad spectrum of developmentally relevant genes and pathways were found to be activated. This study significantly advances the application of probiotics in promoting sustainable aquaculture practices.
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Project description:Streptococcus agalactiae (Lancefield’s group B Streptococcus, GBS) is a major bacterial species of genus Streptococcus and has medical and veterinary importance by affecting mainly humans (Maione et al., 2005; Johri et al., 2006), cattle (Keefe, 1997) and fish (Mian et al., 2009). The GBS is the most important pathogen for the Nile tilapia, a global commodity of the aquaculture sector, causing outbreaks of septicemia and meningoencephalitis (Hernández et al., 2009; Mian et al., 2009). This study aimed to evaluate the global abundancy of proteins among the main genotypes of GBS isolated from fish identified in Brazil using a label free shotgun liquid chromatography-ultra definition mass spectrometry (LC-UDMSE) approach and to compare the differential expression of proteins identified between isolates from fish and human.
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Project description:Meningitis is a complex disease which can be caused by infection with either viral or bacterial pathogens. Viral meningitis is usually a sterile self-limiting disease with a good clinical prognosis, while bacterial meningitis is a potentially more serious disease with a higher mortality rate. Early diagnosis of bacterial meningitis is of paramount importance, as intervention with antimicrobial therapy increases the likelihood of a favourable clinical outcome. Routine diagnosis in many laboratories is still dependent to some degree on traditional methods e.g. culture, though molecular methods have been developed which can give a shorter time to diagnosis. However, there is not as yet a single test format that can detect all bacterial pathogens capable of causing meningitis. In addition, many tests e.g. real-time PCR have a finite limit for multiplexing and do not provide additional information such as strain or serogroup which is useful during outbreaks and for retrospective epidemiological surveillance. To this end we have developed a microarray probe set for detection of meningitis-associated bacterial pathogens including those in the N. meningitidis serogroups. Here we demonstrate utility of this array in specific detection of represented bacterial species and strains and in detection of pathogen signals in cerebrospinal fluid samples from patients with suspected bacterial meningitis. This method shows promise for development as a diagnostic tool; however, we discuss the technical issues encountered and suggest mechanisms to improve resolution of pathogen-specific signals in complex clinical samples. We designed as part of a larger pan-pathogen microarray a sub-set of probes to meningitis-associated bacterial pathogens. We present here data confirming the pathogen-specificity of many of these probes and their potential use in clinical diagnosis through testing on a small number of patient clinical samples using human DNA and no added nucleic acid controls. These data are from single channel Cy3-labelled nucleic acids. Four technical replicates for each feature are included on the array.
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Project description:Molecular characterization of bacterial fish pathogens
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Project description:Vibrio splendidus is one of the main pathogens of aquaculture animals, and iron is the main environmental factor for bacterial growth. Bacteria change in physiological state under the influence of density. This study is to compare the identity and specificity of changes of Vibrio splendidus under the influence of iron and bacterial density.
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