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DRG tissue CSDE1-IP sequencing using sciatic nerve injured and uninjured mice.

ABSTRACT: DRG tissue CSDE1-IP sequencing using sciatic nerve injured and uninjured mice.

PROVIDER: PRJNA1284797 | ENA |

REPOSITORIES: ENA

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DRG tissue CSDE1-IP sequencing using sciatic nerve injured and uninjured mice.

Project description:To determine CSDE1 associated RNAs after injury in sensory neurons, we conducted CSDE1-IP sequencing analysis using dorsal root ganglion (DRG) tissues of wild type mice.

2025-09-01 | GSE301321 | GEO

DRG tissue LARP1-IP sequencing using sciatic nerve injured and uninjured mice.

Project description:DRG tissue LARP1-IP sequencing using sciatic nerve injured and uninjured mice.

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DRG tissue LARP1-IP sequencing using sciatic nerve injured and uninjured mice.

Project description:To determine LARP1 associated RNAs after injury in sensory neurons, we conducted LARP1-IP sequencing analysis using dorsal root ganglion (DRG) tissues of wild type mice.

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DRG tissue CSDE1-RIP and bulk RNA sequencing using sciatic nerve injured and uninjured AAV-Control or AAV-shGpr151 injected mice.

Project description:DRG tissue CSDE1-RIP and bulk RNA sequencing using sciatic nerve injured and uninjured AAV-Control or AAV-shGpr151 injected mice.

| PRJNA1284796 | ENA

DRG tissue CSDE1-RIP and bulk RNA sequencing using sciatic nerve injured and uninjured AAV-Control or AAV-shGpr151 injected mice.

Project description:To determine the effect of Gpr151 mRNA depletion to rp-mRNA operon including RNA-binding protein CSDE1 after injury, we conducted CSDE1-IP sequencing analysis using the dorsal root ganglions(DRGs) of AAV-control and AAV-shGpr151 injected mice.

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DRG tissue RiboTag and bulk RNA sequencing using sciatic nerve injured and uninjured mice.

Project description:DRG tissue RiboTag and bulk RNA sequencing using sciatic nerve injured and uninjured mice.

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Sciatic nerve injury-responsive differential CSDE1 association efficiency of ribosomal protein coding mRNAs

Project description:Gpr151 is an injury-responsive gene that promotes axon regeneration through its interaction with the 5'UTR region of its mRNA transcripts and the RNA-binding protein CSDE1. We found that knocking down or overexpressing the 5'UTR of Gpr151 changes the ribosomal protein mRNA regulon regulated by CSDE1. After the sciatic nerve injury, the association between the ribosomal protein mRNA regulon and CSDE1 was enhanced at dorsal root ganglions(DRGs), but this enhancement was not observed in the AAV-shGpr151 injected mice. Overexpression of 5'UTRmut, which has increased binding affinity to CSDE1, enhanced the ribosomal protein mRNA regulon and its association with CSDE1 in embryonic DRG neurons.

2023-08-18 | GSE236910 | GEO

Expression changes in L4 DRG initiated by sciatic nerve injury

Project description:Expression of L4 DRG after sciatic nerve cut compared to contralateral uninjured DRGs. The "SAMPLE_ID" sample characteristic is a sample identifier internal to Genentech. The ID of this project in Genentech's ExpressionPlot database is PRJ0003322 Keywords: Expression profiling by array

2017-04-26 | GSE96051 | GEO

Ribotag-RNA sequencing data using Csde1-KD dorsal root ganglion(DRG) neurons

Project description:We found that the expression of various ribosomal protein genes is regulated at the translation level, and the post-transcriptional regulator CSDE1 controls their association with ribosomes after sciatic nerve injury. This sequencing data shows neurons without CSDE1 exhibit a deficiency in the recruitment of ribosomal protein mRNAs to ribosomes.

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In vivo analysis of camptothecin effect in primary DRG neuron after sciatic nerve injury

Project description:Analysis of gene expression in injured primary DRG with or without camptothecin (CPT) treatment after sciatic nerve crushing may help us identify critical molecular pathways related to axon regeneration. We performed RNA-sequencing of (i) Naive primary DRG tissues without injury, (ii) Primary DRG tissues with vehicle treatment different time-points (18, 24, 36 hours) after sciatic nerve injury, and (iii) Primary DRG tissues with camptothecin treatment different time-points (18, 24, 36 hours) after sciatic nerve injury.

2020-07-24 | GSE113672 | GEO

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