Project description:To determine LARP1 associated RNAs after injury in sensory neurons, we conducted LARP1-IP sequencing analysis using dorsal root ganglion (DRG) tissues of wild type mice.
Project description:To determine CSDE1 associated RNAs after injury in sensory neurons, we conducted CSDE1-IP sequencing analysis using dorsal root ganglion (DRG) tissues of wild type mice.
Project description:Expression of L4 DRG after sciatic nerve cut compared to contralateral uninjured DRGs. The "SAMPLE_ID" sample characteristic is a sample identifier internal to Genentech. The ID of this project in Genentech's ExpressionPlot database is PRJ0003322 Keywords: Expression profiling by array
Project description:Analysis of gene expression in injured primary DRG with or without camptothecin (CPT) treatment after sciatic nerve crushing may help us identify critical molecular pathways related to axon regeneration. We performed RNA-sequencing of (i) Naive primary DRG tissues without injury, (ii) Primary DRG tissues with vehicle treatment different time-points (18, 24, 36 hours) after sciatic nerve injury, and (iii) Primary DRG tissues with camptothecin treatment different time-points (18, 24, 36 hours) after sciatic nerve injury.
Project description:Purpose: compare the gene expression in whole sciatic DRG of aged mice preceding and after sciatic nerve injury (SNI) compared to the young Results: we found ageing-dependent gene expression changes repressing axonal regeneration following sciatic nerve injury
Project description:Peripheral neurons can regenerate after nerve injury. To determine the transcriptional and post-transcriptional regulation after injury, we conducted total RNA and RiboTag sequencing analysis using sensory neuron-specific RiboTag mice, RPL22HA+/+;Advillin-Cre+.
Project description:To identify potential regeneration-associated genes, rat dorsal root ganglia (DRG) were lesioned and then sampled at 4, 8, 12, 24, 48, 148, or 296 hrs A total of 23 samples were examined in 8 time points with 2-3 replicates each. For each array, lesioned and uninjured DRG samples were run in a two-color experiment. ----------------------------------------------------- submitters of this record cannot locate the raw data