Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA129509 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:This SuperSeries is composed of the following subset Series: GSE21311: Maternal influences on the transmission of leukocyte gene expression profiles in population samples (Red Cross Donors) GSE21342: Maternal influences on the transmission of leukocyte gene expression profiles in population samples (mother and child) Refer to individual Series
2011-01-01 | E-GEOD-21345 | biostudies-arrayexpress
Project description:Maternal influences on the transmission of leukocyte gene expression profiles in population samples (Red Cross Donors)
| PRJNA129733 | ENA
Project description:This study contrasts the expression profiles of peripheral blood leukocytes from third trimester pregnant mothers, with cord blood leukocytes from their newborn children. It is a companion to (GSE21311). After normalization for RNA integrity, major principal components of the variation were found to distinguish individuals. Transmission of gene expression profiles from mother to child was documented, along with differences between gestational diabetic, obese, and normal weight mothers and their children.
2011-01-01 | GSE21342 | GEO
Project description:This study contrasts the expression profiles of peripheral blood leukocytes from third trimester pregnant mothers, with cord blood leukocytes from their newborn children. It is a companion to (GSE21311). After normalization for RNA integrity, major principal components of the variation were found to distinguish individuals. Transmission of gene expression profiles from mother to child was documented, along with differences between gestational diabetic, obese, and normal weight mothers and their children. 56 individulas (Brisbane, Australia) were sampled for the mother-newborn study, under informed consent. 19 mothers sample were collected in the last month of pregnancy (between 30th and 36th week of pregnancy) and 37 cord blood samples were obtained at birth from newborn babies. Mothers having BMI values over 30 before pregnancy were classified as obese. From the 37 newborn babies, 10 were born to obese mothers, 8 to gestational diabetic mothers (with a wide range of body mass indices), and 19 to normal-weight mothers. There were 16 mother-newborn pairs in the dataset. RNA from each was hybridized to an Illumina HT12 array.
2011-01-01 | E-GEOD-21342 | biostudies-arrayexpress
Project description:Genome-wide DNA methylation profiling of 251 whole-blood samples from children aged 2 years from the ENID mother-child cohort in The Gambia.
2017-11-23 | GSE99863 | GEO
Project description:Influenza virus transmission between mothers and nursing-infants has not been investigated although mothers and infants often develop severe disease. Ferrets are considered the most appropriate model for influenza studies. We investigated influenza transmission in infant and nursing-mother ferrets. Influenza infected infants transmitted virus to mother mammary glands leading to live virus excretion in milk and influenza virus positive mammary gland epithelial cells. Global gene expression analysis showed down-regulation of milk production and induction of breast involution and oncogenesis pathways. Our results provide insight into influenza transmission between mothers and infants which may impact fields of infectious disease, maternal/infant health and neoplasm etiology. Total RNA was obtained from nursing mother ferret mammary glands at days 3/4 and 6/7 post-intranasal kit infection with 10^5 EID50 A/California/07/2009 (H1N1). Total RNA was also collected from uninfected control nursing mother mammary gland tissues (n = 3). Changes in gene expression relative to uninfected tissue controls were then investigated.
2015-09-10 | E-GEOD-63082 | biostudies-arrayexpress
Project description:HSP child-mother pairs and matched healthy child-mother pairs sequence.
| PRJNA497481 | ENA
Project description:Congenital toxoplasmosis is a fetal infection following the transplacental transmission of Toxoplasma gondii in a mother who seroconverted during pregnancy. Neonatal diagnosis has recently been improved through the identification by L’Ollivier et al. and Peyclit et al. of a congenital toxoplasmosis pathognomonic marker: the IgM triplet, corresponding to three bands of high molecular weight of 75, 90 and 100 kDa respectively found on the immunoblot pair profile mother-child. This is a new concept, as these three IgM bands do reflect an immunological response against proteins involved in mother-to-child transmission of Toxoplasma gondii. These proteins could be Toxoplasma gondii secreted effectors or not playing a role in the processes of invasion, modulation of the host cell immune system as well as in parasitic virulence. In this study, immunoproteomic techniques allowed us to identify 32 interesting protein spots on immunoblot, including 4 interesting spots specific to the IgM triplet. After protein identification of these spots by LC-MS/MS technique, we showed here that several Toxoplasma gondii proteins were good candidates for the IgM triplet. It turns out that each of these proteins is, directly or indirectly, involved in the process of cellular invasion and therefore probably in the process of transplacental invasion of Toxoplasma gondii. The identification of these proteins opens several fields of future diagnostic and therapeutic research that would improve management of congenital toxoplasmosis.
2025-12-08 | PXD060424 | Pride