ABSTRACT: Draft genome sequence of Stenotrophomonas maltophilia strain TUM26315, a bloodstream isolate with resistance to cefiderocol and aztreonam with ceftazidime-avibactam
Project description:Using in vitro directed evolution, we show that mismatch repair-deficient Pseudomonas aeruginosa can engage novel resistance mechanisms to ceftazidime-avibactam.
2021-08-30 | GSE180086 | GEO
Project description:Resistance to ceftazidime-avibactam and cefiderocol in clinical Enterobacter isolate.
Project description:We sought to determine how a cystic fibrosis isolate of Stenotrophomonas maltophilia responds to relevant pH gradients (pH 5, 7, and 9) by growing the bacterium in phosphate buffered media and conducting RNAseq experiments. Our data suggests acidic conditions are stressful for strain FLR19, as it responded by increasing expression of stress-response and antibiotic-resistance genes.
2018-10-17 | GSE121347 | GEO
Project description:Cefiderocol-resistance induced in patients with Klebsiella pneumoniae bloodstream infections during ceftazidime/avibactam-based treatment
Project description:Natural Cefiderocol Resistance in Stenotrophomonas maltophilia Genogroup 4
| PRJEB84958 | ENA
Project description:Ceftazidime-avibactam and cefiderocol resistance in KPC-2-producing Klebsiella pneumoniae ST323 isolates
| PRJNA1215006 | ENA
Project description:Optimal Treatment of Ceftazidime-Avibactam and Aztreonam-Avibactam Against Bloodstream Infections or Lower respiratory tract Infections Caused by extensively drug-resistance or pan drug-resistance (XDR/PDR) Pseudomonas aeruginosa
| PRJNA967114 | ENA
Project description:Ceftazidime-avibactam Resistance in Klebsiella pneumoniae
Project description:The goal of this study was to elucidate genes that are employed by the bacterivorous nematode Caenorhabditis elegans to respond to the emerging nosocomial bacterial pathogen Stenotrophomonas maltophilia.
Project description:Stenotrophomonas maltophilia is an emerging multidrug resistance opportunistic pathogen affecting immunocompromised and hospitalized patients. S. maltophilia is an environmental bacterium which adapts to human body and causing infection. S. rhizophilia, a non-pathogenic and phylogenetic neighbour of S. maltophilia is unable to grow at human body temperature. Thus, to understand molecular mechanism underlying the adaptation of S. maltophilia at human body temperature, we performed the comparative transcriptome analysis of S.maltophilia at 28 °C (representative for the environmental niches) and 37 °C (representative for human body) by using RNA-Seq. The major temperature-induced genes include genes for Type IV secretion system, aerotaxis, and cation diffusion facilitator family transporter suggesting its potential role in the adaptation and virulence of S. maltophilia. The downregulated genes at 37 °C includes the genes for the cell motility, energy generation and metabolism, lipid metabolism, translation, amino acid metabolism and transport, replication and repair, inorganic ion and transport metabolism lipid metabolism, coenzyme metabolism.
