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Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding

ABSTRACT: Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding

PROVIDER: PRJNA1307539 | ENA |

REPOSITORIES: ENA

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Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding [bulk RNA-Seq]

Project description:Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding [bulk RNA-Seq]

| PRJNA1308517 | ENA

Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding

Project description:The lateral hypothalamus (LH) is a highly heterogenous brain region regulating hunger and motivated behaviours. In zebrafish, the LH exhibits distinct neural activity across hunger, feeding and satiety staes. In this study, we have generated a zebrafish LH transcriptomic dataset to profile cellular diversity and molecular signatures underlying feeding behaviour.

2025-08-18 | GSE305744 | GEO

Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding [bulk RNA-Seq]

Project description:The lateral hypothalamus (LH) is a highly heterogenous brain region regulating hunger and motivated behaviours. Inzebrafish, the LH exhibits distinct neural activity across hunger, feeding and satiety staes. In this study, we have generated a zebrafish LH transcriptomic dataset to profile cellular diversity and molecular signatures underlying feeding behaviour.

2025-08-20 | GSE305956 | GEO

Obesity Remodels Activity and Transcriptional State of a Lateral Hypothalamic Brake on Feeding

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Molecular codes defining lateral hypothalamic sleep regulating neurons

Project description:Molecular codes defining lateral hypothalamic sleep regulating neurons

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Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity

Project description:Sleep deficiency is prevalent in modern society and has become one of the major causes of metabolic diseases. The hypothalamus, as a critical brain region of hormone secretion, can be affected by disrupted sleep-wakefulness. Therefore, we would like to identify new hypothalamic hormones that affected by sleep, which is benefited for treatment of obesity

2025-01-27 | PXD059981 | Pride

Obesity Remodels Activity and Transcriptional State of a Lateral Hypothalamic Brake on Feeding

Project description:Obesity Remodels Activity and Transcriptional State of a Lateral Hypothalamic Brake on Feeding

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Hypothalamic thyroid hormone deficiency underlies reversible anorexia in a mammalian hibernator

Project description:Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-lined ground squirrels lasts for 5–7 months and comprises weeks of hypometabolic, hypothermic torpor interspersed with 24–48-hour periods of an active-like interbout arousal (IBA) state. We show that ground squirrels, who endure the entire hibernation season without food, have negligible hunger drive during IBAs. We further demonstrate that squirrels exhibit reversible inhibition of the hypothalamic feeding center, such that hypothalamic arcuate nucleus neurons have reduced sensitivity to the orexigenic and anorexigenic effects of ghrelin and leptin, respectively. However, hypothalamic infusion of thyroid hormone during an IBA is sufficient to rescue hibernation anorexia. Our results reveal that thyroid hormone deficiency underlies hibernation anorexia and demonstrate the functional flexibility of the hypothalamic feeding center.

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Fasting and feeding hormones differentially impact activity dynamics of transcriptionally distinct lateral hypothalamic glutamate projection neurons

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Molecular codes defining lateral hypothalamic sleep regulating neurons

Project description:Hypothalamic hypocretin (HCRT) and melanin concentrating hormone (MCH) have multiple functions including sleep and metabolism. How these neuropeptides are produced and involved in divers functions remain unknown. We developed methods to sort and purify HCRT and MCH neurons from mouse hypothalamus. RNA-sequencing revealed key factors of fate determination for HCRT (Peg3, Ahr1, Six6, Nr2f2 and Prrx1) and MCH (Lmx1, Gbx2 and Peg3) neurons. Amongst these, loss of Peg3 in mice significantly reduces HCRT and MCH cell numbers while knock-down of Peg3 ortholog in zebrafish completely abolishes their expression resulting in a two fold increase in sleep. The transcriptome results were used to produce HCRT and MCH neurons from induced pluripotent stem cells (iPSCs) and ascorbic acid was found necessary for HCRT and BMP7 for MCH cell differentiation. Our results provide a platform to understand the development and expression of HCRT and MCH and their multiple functions in health and disease.

2019-09-01 | GSE126330 | GEO

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