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Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding [bulk RNA-Seq]

ABSTRACT: Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding [bulk RNA-Seq]

PROVIDER: PRJNA1308517 | ENA |

REPOSITORIES: ENA

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Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding

Project description:Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding

| PRJNA1307539 | ENA

Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding

Project description:The lateral hypothalamus (LH) is a highly heterogenous brain region regulating hunger and motivated behaviours. In zebrafish, the LH exhibits distinct neural activity across hunger, feeding and satiety staes. In this study, we have generated a zebrafish LH transcriptomic dataset to profile cellular diversity and molecular signatures underlying feeding behaviour.

2025-08-18 | GSE305744 | GEO

Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feeding [bulk RNA-Seq]

Project description:The lateral hypothalamus (LH) is a highly heterogenous brain region regulating hunger and motivated behaviours. Inzebrafish, the LH exhibits distinct neural activity across hunger, feeding and satiety staes. In this study, we have generated a zebrafish LH transcriptomic dataset to profile cellular diversity and molecular signatures underlying feeding behaviour.

2025-08-20 | GSE305956 | GEO

Obesity Remodels Activity and Transcriptional State of a Lateral Hypothalamic Brake on Feeding

Project description:We demonstrate that high fat diet (HFD)-induced obesity alters the transcriptional state of lateral hypothalamic glutamate neurons in mice.

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Molecular codes defining lateral hypothalamic sleep regulating neurons

Project description:Molecular codes defining lateral hypothalamic sleep regulating neurons

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Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity

Project description:Sleep deficiency is prevalent in modern society and has become one of the major causes of metabolic diseases. The hypothalamus, as a critical brain region of hormone secretion, can be affected by disrupted sleep-wakefulness. Therefore, we would like to identify new hypothalamic hormones that affected by sleep, which is benefited for treatment of obesity

2025-01-27 | PXD059981 | Pride

Obesity Remodels Activity and Transcriptional State of a Lateral Hypothalamic Brake on Feeding

Project description:Obesity Remodels Activity and Transcriptional State of a Lateral Hypothalamic Brake on Feeding

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Hypothalamic thyroid hormone deficiency underlies reversible anorexia in a mammalian hibernator

Project description:Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-lined ground squirrels lasts for 5–7 months and comprises weeks of hypometabolic, hypothermic torpor interspersed with 24–48-hour periods of an active-like interbout arousal (IBA) state. We show that ground squirrels, who endure the entire hibernation season without food, have negligible hunger drive during IBAs. We further demonstrate that squirrels exhibit reversible inhibition of the hypothalamic feeding center, such that hypothalamic arcuate nucleus neurons have reduced sensitivity to the orexigenic and anorexigenic effects of ghrelin and leptin, respectively. However, hypothalamic infusion of thyroid hormone during an IBA is sufficient to rescue hibernation anorexia. Our results reveal that thyroid hormone deficiency underlies hibernation anorexia and demonstrate the functional flexibility of the hypothalamic feeding center.

2024-04-03 | GSE242381 | GEO

Fasting and feeding hormones differentially impact activity dynamics of transcriptionally distinct lateral hypothalamic glutamate projection neurons

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Bidirectional regulation of social memory by two distinct types of GABAergic neurons in the lateral septum

Project description:Humans and animals memorize and recognize familiar conspecifics during social interactions, known associal memory. While the hippocampus is crucial for social memory, the dynamic regulation social memory, particularly the negative regulation, remains unclear. Here, we identified two molecularly distinct subpopulations of GABAergic neurons in the mouse lateral septum(LS) expressing somatostatin(SST) and calbindin1(CB), respectively, with complementary distribution patterns. Activation of SST+ neurons enhances social memory acquisition, whereas activation of CB+ neurons inhibits it. Optogenetic manipulation of SST+ neurons regulates theta rhythm oscillations, correlating with their impact on social memory. SST+-dLS neurons and CB+-vLS neurons preferentially receive stronger excitatory inputs from the dorsal (vCA1d) and ventral(vCA1v) parts of vCA1, respectively. The vCA1d→SST+-dLS→lateral hypothalamic area (LHA) circuit positively regulates social memory acquisition, whereas thevCA1v→CB+-vLS→anterior hypothalamic nucleus (AHN) pathway negatively regulates it. This study uncovers two parallel subcortical neural circuits underpinning the dynamic regulation of social memory.

2026-01-13 | GSE273782 | GEO

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