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Drosophila melanogaster

ABSTRACT: RNA sequencing in fly heads to examine the effect of spermidine feeding on transcription in the ageing fly brain.

PROVIDER: PRJNA169561 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR518259.fastq.gz	Fastqsanger.gz
	SRR518260.fastq.gz	Fastqsanger.gz
	SRR518261.fastq.gz	Fastqsanger.gz
	SRR518262.fastq.gz	Fastqsanger.gz
	SRR935153.fastq.gz	Fastqsanger.gz

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RNA sequencing in fly heads to examine the effect of spermidine feeding on transcription in the ageing fly brain.

2013-09-01 | GSE38998 | GEO

RNA sequencing in fly heads to examine the effect of spermidine feeding on transcription in the ageing fly brain.

Project description:mRNA sequencing was used to identify genome wide transcriptional changes occuring in fly heads in response to spermidine feeding. This study shed light on the molecular mechanisms through wich spermidine can protect against age-dependent memory impairment. mRNA profiles from 3 and 10 day old Drosophila melanogaster heads were generated in duplicate by deep sequencing using Illumina GAIIx. mRNA profiles from flies that were fed food with 5mM spermidine were compared to profiles from flies that had no spermidine in thier food.

2013-09-01 | E-GEOD-38998 | biostudies-arrayexpress

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Project description:Our objective was to identify candidate genes that contribute to the long 31-hour circadian period previously observed in DGRP_892. We performed transcriptional profiling of whole fly heads from two genotypes: DGRP_892, and Canton-S B, a line with a normal 24-hour circadian period. We collected fly heads every two hours over a 24-hour period. We quantified differential expression among genotype, time, and sex.

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Project description:We used long-oligonucleotide microarrays to investigate whether alternative splicing in Drosophila is regulated in a sex-, stage-, or tissue-specific manner. To examine sex-specific splicing, we compared gene expression profiles of male and female pupae 12 hours after pupariation. To examine stage-specific splicing, we compared expression profiles of mixed-sex, 0-24 hour old embryos and mixed-sex, 12 hour old pupae. To examine tissue-specific splicing, we compared expression profiles of adult male heads and abdomens 24-48 hours after eclosion. To examine tissue-specific splicing, we compared expression profiles of adult male heads and abdomens at 24-48 hours after eclosion. Keywords: tissue-specific expression profiles

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