Project description:In order to explore the intervention effect of Tianhezhuifeng liquid extract on rheumatoid arthritis, we constructed an animal model of rheumatoid arthritis We then performed gene expression profiling analysis using data obtained from synovial tissues of typical samples
Project description:Rheumatoid arthritis (RA) is a complex and clinically heterogeneous autoimmune disease. Microarray analysis of 83 synovial samples provides insight into the expression-level differences between patients at the site of disease activity. Synovial samples from Rheumatoid Arthritis patients were obtained during joint resection and profiled using microarrays.
Project description:This dataset contains processed 10x Genomics single-cell RNA-seq data from synovial fluid cells of three treatment-naive osteoarthritis (OA) patients. These OA samples were used as controls in the published Nature Communications study "Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF/JAK inhibitor treatment" (doi: 10.1038/s41467-025-57361-0), which profiled synovial fluid immune cells to characterize rheumatoid arthritis-associated cellular states and treatment-related immune remodeling.
Project description:The purpose of this study was to investigate the transcriptomic heterogeneity in synovial tissue of early untreated rheumatoid arthritis patients in association with clinical data
