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Coccidioides immitis

ABSTRACT: Coccidioidomycosis increases its area of geographic risk: Molecular detection and isolation of Coccidioides immitis in Washington State from soil associated with recent human infection

PROVIDER: PRJNA245906 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR1292220_1.fastq.gz	Fastqsanger.gz
	SRR1292220_2.fastq.gz	Fastqsanger.gz
	SRR1292221_1.fastq.gz	Fastqsanger.gz
	SRR1292221_2.fastq.gz	Fastqsanger.gz

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Coccidioides immitis

Project description:Coccidioides immitis Raw sequence reads

| PRJNA820037 | ENA

Gene expression in human fungal pathogen Coccidioides immitis changes as mycelia differentiate into spherules and mature

2013-07-11 | GSE44225 | GEO

Gene expression in human fungal pathogen Coccidioides immitis changes as mycelia differentiate into spherules and mature

Project description:Coccidioides immitis (C. immitis) is a dimorphic fungus that causes disease in mammals including human beings. It grows as a mycelium in the soil but differentiates into a pathogenic structure called a spherule in the host. We compared the transcriptome of C. immitis mycelia and day 2 and day 8 spherules grown in vitro using a custom custom oligonucleotide microarray from Nimblegen. C. immitis RS strain isolated from infected mice was grown on agar. Arthroconidia was harvested and inoculated into mycelial spores. RNA was extracted from spores at different days post-inoculation and hybridized to a custom Nimblegen array, in order to identify differentially expressed genes between mycelia and spherules.

2013-07-11 | E-GEOD-44225 | biostudies-arrayexpress

Coccidioides immitis

Project description:Pathogenic fungus that is morphologically indistinguishable from Coccidioides posadasii both cause the disease coccidioidomycosis

| PRJNA12821 | ENA

Factors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitis infection.

2012-09-10 | GSE40379 | GEO

Coccidioides posadasii

Project description:A dimorphic ascomycete causing coccidioidomycosis and morphologically indistinguishable from Coccidioides immitis.

| PRJNA10735 | ENA

Factors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitis infection.

Project description:Mouse strains have been identified that are resistant (i.e. DBA/2) or susceptible (i.e. C57BL/6) to infection from pathogenic fungus Coccidioides immitis. However, the genetic and immunological basis for this difference has not been fully characterized. Microarray technology was used to identify genes that were differentially expressed in lung tissue between resistant DBA/2 and sensitive C57BL/6 mice after infection with C. immitis. C57BL/6 and DBA/2 mice were infected with arthoconidia of C. immitis and RNA was extracted at different days post-infection and hybridized to Affymetrix microarrays (MGU74Av2), in order to identify differentially expressed genes between the two strains.

2012-09-10 | E-GEOD-40379 | biostudies-arrayexpress

Coccidioides immitis RS strain:RS

Project description:Coccidioides immitis RS strain:RS Transcriptome or Gene expression

| PRJNA169242 | ENA

RNA-seq transcriptional analysis of mouse lung tissue with and without Coccidioides immitis lung infection

Project description:Our previous data suggested that CXC ELR+ chemokines might be involved in neutrophil recruitment to the lungs during Coccidioides infection. To test that hypothesis, we infected IL-8R2 (Cxcr2) KO mice on a BALB/c background. IL-8R2 KO mice had fewer neutrophils in infected lungs than BALB/c controls, but unexpectedly the IL-8R2 KO mice also had 10-fold fewer organisms in their lungs than did control mice. To better understand the differences in IL-8R2 KO mouse lungs during Coccidioides infection we performed RNA-seq on lung tissue from uninfected and Coccidioides immitis infected mouse lungs in control and IL-8R2 (Cxcr2) KO mice. IL-8R2 KO mouse lungs had higher expression of genes associated with lymphocyte activation, including Th1 and Th17-related genes Ifnγ and Il17a and transcription factors Stat1 and Rorc. Bronchial alveolar lavage (BAL) fluid from infected IL-8R2 KO mice similarly contained more IL-17A and IFNγ.

2020-09-14 | GSE146594 | GEO

Functional characterization of the transcription programs underlying phase transition in the BSL3 pathogen Coccidioides immitis

Project description:Coccidioidomycosis (Valley Fever) is an emerging endemic fungal infection with a rising incidence and an expanding geographic range. It is caused by Coccidiodes, which are thermally dimorphic fungi that grow as mycelia in soil but transition in the lung to form pathogenic spherules. The regulatory mechanisms underlying this transition are not understood. Exploiting capped small (cs)RNA-seq, which identifies actively initiated stable and unstable transcripts and thereby detects acute changes in gene regulation with remarkable sensitivity, here we report the changes in architectural organization and key sequence features underlying phase transition of this highly pathogenic fungus. Spherule transition was accompanied by large-scale transcriptional reprogramming, functional changes in transcript isoforms, and a massive increase in promoter-distal transcription of ncRNAs. Analysis of spherule-activated regulatory elements revealed a motif predicted to recruit a WOPR family transcription factor, which are known regulators of virulence in other fungi. We identify CIMG_02671 as a C. immitis WOPR homologue and show that it activates transcription in a WOPR motif-dependent manner, suggesting it is an important regulator of pathogenic phase transition. Collectively, this also highlights csRNA-seq as a powerful means to identify transcriptional mechanisms that control pathogenesis.

2022-01-05 | GSE179468 | GEO

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