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Anopheles gambiae

ABSTRACT: Insights into the epigenomic landscape of the human malaria vector Anopheles gambiae

PROVIDER: PRJNA256184 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1525400_1.fastq.gz	Fastqsanger.gz
	SRR1525400_2.fastq.gz	Fastqsanger.gz
	SRR1525401_1.fastq.gz	Fastqsanger.gz
	SRR1525401_2.fastq.gz	Fastqsanger.gz
	SRR1525402_1.fastq.gz	Fastqsanger.gz

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Insights into the epigenomic landscape of the human malaria vector Anopheles gambiae

2014-09-04 | GSE59773 | GEO

Anopheles gambiae immune responses to human and rodent Plasmodium parasite species

Project description:Transmission of malaria is dependent on the successful completion of the Plasmodium lifecycle in the Anopheles vector. Major obstacles are encountered in the midgut tissue, where most parasites are killed by the mosquito’s immune system. In the present study, DNA microarray analyses have been used to compare Anopheles gambiae responses to invasion of the midgut epithelium by the ookinete stage of the human pathogen Plasmodium falciparum and the rodent experimental model pathogen P. berghei. Invasion by P. berghei had a more profound impact on the mosquito transcriptome, including a variety of functional gene classes, while P. falciparum elicited a broader immune response at the gene transcript level. Ingestion of human malaria-infected blood lacking invasive ookinetes also induced a variety of immune genes, including several anti-Plasmodium factors. Keywords: Anopheles gambiae, Plasmodium falciparum, ookinete, invasion, innate immunity

2007-08-15 | GSE8789 | GEO

Anopheles gambiae brain proteomic analysis

Project description:Proteomic analysis of Anopheles gambiae brain tissue after in-gel trypsin digestion. To gain insights into neurobiology of the Anopheles gambiae mosquito, we carried out a proteomic analysis of its brain using a comprehensive proteomic approach.

2016-12-20 | PXD000630 | Pride

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Project description:The mosquito Anopheles gambiae is the principal vector of malaria

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Microarray analysis of Wolbachia infected Anopheles gambiae Sua5B cells

Project description:Wolbachia, an endosymbiotic bacterium, is being investigated as a vector control agent in several insect species. Along with the well known classical reproductive parasitism Wolbachia employs against its host to spread within the population, it is emerging that the bacteria can protect the host against pathogens and reduced pathogen transmission. Anopheles mosquitoes, which transmit malaria, have never been found to harbour Wolbachia in nature, and despite numerous transinfection attempts, no stable line has been developed. However recently, two strains of Wolbachia, wAlbB from Aedes albopictus, and wRi from Drosophila simulans were cultured in Anopheles gambiae Sua5B cells. These cell lines provides an amenable system to study Wolbachia-Anopheles interaction in the absence of a stable transinfected line. It has been proposed that the compromised vector competence of Wolbachia infected insects is due to an up regulation of the basal immune state. We therefore completed a genome wide expression profile of Wolbachia infected Anopheles, assessing both wAlbB and wRi infected cells in parallel against uninfected Sua5B cells.

2011-03-02 | GSE23215 | GEO

Proteomic investigation on Anopheles gambiae in Burkina Faso related to insecticide pressures from different climatic regions

Project description:In Sub-Saharan Africa, Anopheles gambiae Giles (Diptera: Culicidae) largely contributes to malaria transmission, in direct relation to environmental conditions influencing the vector ecology. Therefore, our study aimed to compare the proteomes of An. gambiae according to varying insecticide pressures associated to cotton crops also integrating different population origins from two climatic regions of Burkina Faso.

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Project description:Gene Expression Profiling Data of African Malaria Vector Anopheles gambiae Aging

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Insights into the epigenomic landscape of the human malaria vector Anopheles gambiae

Project description:We characterize the epigenome of the human malaria vector Anopheles gambiae in midgut cells by mapping the distribution and levels of two post-translational histone modifications, H3K27ac and H3K27me3. These histone profiles were then correlated with levels of gene expression obtained by RNA-seq. ChIP-seq and RNA-seq were performed on adult female A. gambiae midguts. RNA-seq was performed on adult female A. gambiae salivary glands.

2014-09-04 | E-GEOD-59773 | biostudies-arrayexpress

Gene Expression Profiling Data of African Malaria Vector Anopheles gambiae Aging

Project description:Senescence is a biological phenomenon experienced by all living eukaryote organisms. Genome-wide gene expression associated with aging has been explored in model organisms such as Drosophila melanogaster and Caenorhabditis elegans, but this has not been well understood in African malaria vector, Anopheles gambiae. Gene expression profiling using DNA microarray allows for simultaneous study of changes in mRNA levels for thousands of genes. This study examined genome-wide gene expression during aging process in An. gambiae. The influence of blood feeding on gene expression was also examined. The data can be used to further our understanding of mosquito senescence and identify biomarkers for mosquito age grading.

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2025-10-17 | PXD060698 | Pride

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