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Mus musculus

ABSTRACT: Comprehensive role of Zfp217 in m6A methylation [RIP-seq]

PROVIDER: PRJNA274810 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1793126_1.fastq.gz	Fastqsanger.gz
	SRR1793126_2.fastq.gz	Fastqsanger.gz
	SRR1793127_1.fastq.gz	Fastqsanger.gz
	SRR1793127_2.fastq.gz	Fastqsanger.gz
	SRR1793128_1.fastq.gz	Fastqsanger.gz

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Project description:Comprehensive role of Zfp217 in m6A methylation [ChIP-seq]

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Mus musculus

Project description:Comprehensive role of Zfp217 in m6A methylation [RNA-seq]

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Mus musculus

Project description:Comprehensive role of Zfp217 in m6A methylation [RNA-seq RA]

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Project description:Comprehensive role of Zfp217 in m6A methylation

| PRJNA274808 | ENA

Zfp217 orchestrates m6A mRNA methylation and gene expression to promote adipogenic differentiation

Project description:We performed RNA sequencing (RNA-seq) and m6A methylated RNA immunoprecipitation sequencing (MeRIP-seq) in control and Zfp217 knockout 3T3L1 cells with MDI treatment for 0d and 2d Loss-of-function study demonstrates that Zfp217 deficiency impaired adipogenesis together with a global increase of m6A modification in 3T3L1cells. To gain an overview of the global role of Zfp217 in adipogenesis, we performed RNA sequencing (RNA-seq) in control and Zfp217 knockout 3T3L1 cells with MDI treatment for 0d and 2d and identified 12,188 and 11,566 different expressed genes (DEG) for 0d and 2d, respectively. Next, to elucidate the mechanism by which Zfp217 regulates m6A restriction, m6A methylated RNA immunoprecipitation sequencing (MeRIP-seq) was used to analyze the m6A mRNA methylation in control and Zfp217 knockout 3T3L1 cells with MDI treatment for 0d and 2d, and identified 3149 and 294 of m6A peaks experienced an increase in m6A RNA modification after Zfp217 depletion, respectively.

2019-04-17 | GSE119564 | GEO

YTHDF3 improves translation initiation of mRNAs with N6-methyladenosine methylation at 5’ untranslated region by facilitating eIF2AK2 recruitment in oxaliplatin-resistant colorectal cancer - RIP-seq dataset

Project description:Oxaliplatin as a first-line drug frequently causes the chemo-resistance on colorectal cancer (CRC). N6-methyladenosine (m6A) methylation has been largely acknowledged in multiple biological functions. However, the molecular mechanisms underlying the m6A methylation in modulating anticancer drug resistance in CRC are still obscure. In present study, RIP-seq was conducted to investigate the occupancy of N6-methyladenosine RNA binding protein 3 (YTHDF3) served as “readers” that can recognize m6A modification site in HCT116 cells with oxaliplatin resistance (HCT116R). Then, YTHDF3 was knockdown by siRNA in HCT116 cells with oxaliplatin resistance, and RIP-seq was further conducted to investigate m6A methylation of HCT116, HCT116R and HCT116R cells with YTHDF3 knockdown.

2022-02-04 | E-MTAB-11321 | biostudies-arrayexpress

Comprehensive role of Zfp217 in m6A methylation [MeRIP-seq]

Project description:Many transcriptional and epigenetic networks must be integrated to maintain self-renewal and pluripotency in embryonic stem cells (ESCs) and to enable induced pluripotent stem cell (iPSC) reprogramming. Here, we explore the role of Zfp217 as a key transcriptional factor in maintaining ES cell self-renewal by performing meRIP analysis in control and Zfp217-depleted mouse stem cells. Examination of m6A levels from total RNA in control and Zfp217 shRNA infected mouse stem cells

2015-10-30 | E-GEOD-65734 | biostudies-arrayexpress

Comprehensive role of Zfp217 in m6A methylation [RNA-seq]

Project description:Comprehensive RNA-seq experiments in control and zfp217 shRNA infected cells delineate a Zfp217-driven network required for ES cell self-renewal.

2015-10-30 | GSE65731 | GEO

Comprehensive role of Zfp217 in m6A methylation [RNA-seq]

Project description:Comprehensive RNA-seq experiments in control and zfp217 shRNA infected cells delineate a Zfp217-driven network required for ES cell self-renewal. RNA-seq was used to measure gene expression levels in luciferase control and Zfp217 short hairpin RNA (shRNA) infected mouse stem cells

2015-10-30 | E-GEOD-65731 | biostudies-arrayexpress

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