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Food metagenome

ABSTRACT: Biological ingredient analysis of traditional Chinese medicine preparation based on high-throughput sequencing: more stories on a variety of TCM preparations

PROVIDER: PRJNA280921 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1970520_1.fastq.gz	Fastqsanger.gz
	SRR1970520_2.fastq.gz	Fastqsanger.gz
	SRR2001261_1.fastq.gz	Fastqsanger.gz
	SRR2001261_2.fastq.gz	Fastqsanger.gz
	SRR2002348_1.fastq.gz	Fastqsanger.gz

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food metagenome

Project description:Traditional Chinese Medicine Metagenome

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Project description:As a well-known traditional Chinese medicine (TCM) prescription, Xin-Sheng-Hua Granule (XSHG) has been applied in China for more than thirty years to treat postpartum diseases, especially anaemia. However, the underlying therapeutic mechanisms of XSHG for anaemia were still unclear.

2018-01-30 | MSV000081992 | MassIVE

Effects of Cinnamomum ramulus (CR) on expression profiles effects of cancer cell lines

Project description:Cinnamomi ramulus (CR) is one of the most widely used traditional Chinese medicine (TCM) with anti-cancer effects. Analyzing transcriptomic responses of different human cell lines to TCM treatment is a promising approach to understand the unbiased mechanism of TCM. This study treated ten cancer cell lines with different CR concentrations, followed by mRNA sequencing.

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Expression data from whole blood sample of eight kinds of TCM syndromes of rheumatoid arthritis patients.

Project description:To explore the biological connotation of eight syndromes of Rheumatoid Arthritis (RA) from the syndrome-symptom association network, and the relationship between the clinical characteristics of various syndromes and their key network target genes and pathways, which may offer clinicians auxiliary tools for diagnosis and treatment of RA patients with various traditional Chinese medicine (TCM) syndromes and promoting the developments of TCM Syndrome Theory. We used microarrays to detail the biological connotation of five syndromes (D-H, N) of Rheumatoid Arthritis (RA) and identified distinct classes of up-regulated and down-regulated genes during this process.

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Proteomic of Chaihu-Shugan-San (CSS), Rou Gan, and Shu Gan treat chronic unpredictable mild stress (CUMS) rat with Tandem Mass Tags

Project description:Chaihu-Shugan-San (CSS) is a classical prescription used to treat depression. According to the traditional Chinese medicine (TCM) principle, the 2 decomposed recipes in CSS exert synergistic effects, including Shu Gan (stagnated Gan-Qi dispersion) and Rou Gan (pain alleviation). However, the specific mechanism and compatibility rule remain to be explored. We aimed to analyze the advantage of TCM compatibility in CSS prescriptions and explore its anti-depression mechanisms.

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NGR1 reduces neuronal apoptosis through regulation of ITGA11 following subarachnoid hemorrhage

Project description:Subarachnoid hemorrhage (SAH), a prevalent cerebrovascular condition associated with a high mortality rate, frequently results in neuronal apoptosis and an unfavorable prognosis. Recent research has indicated that the adjunctive use of Traditional Chinese medicine (TCM) with surgical interventions exerts a therapeutic impact on SAH. Nevertheless, the mechanism by which TCM mediates apoptosis following SAH remains unclear. In the present study, HT22 mouse neuronal cells were exposed to Oxyhemoglobin (OxyHb) to establish an in vitro model of SAH. The results indicated that treatment with Notoginsenoside R1 (NGR1) alleviated the short-term neurological deficits, reduced the expression of apoptosis-related proteins, and mitigated brain edema in mice. Similarly, it attenuated OxyHb-induced apoptosis of HT22 neurons. Furthermore, RNA-seq analysis was used to examine the transcriptomic changes between HT22 cells stimulated with OxyHb alone and those treated with NGR1 concurrently or independently. The RNA-seq results revealed significant alterations in the expression levels of apoptosis-related genes in OxyHb-stimulated HT22 cells upon administration of NGR1. This study explored the potential mechanism by which NGR1 mitigates neuronal apoptosis, presenting a novel therapeutic approach for treating SAH through the use of a single TCM ingredient.

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GNPS - Integrated metabolomics and network pharmacology approach to explain possible action mechanisms of Xin-Sheng-Hua Granule for treating anaemia

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Project description:We studied the radiation effect on cell culture model of oral mucositis. The musositis model (tissues) used is an organotypic model which consisted of 3-dimensional (3-D) cell cultures of primary human oral keratinocytes. The tissues were purchased from MatTek corporation (Ashland, MA) and were grown on top of microporous membrane and supplemented with MatTek serum free media. These tissues were irradiated with 12 Gy. Six hours after the irradiation the tissues were cut in half. Half of the tissue was used to extract total RNA (RNeasy Plus Mini kit, Qiagen, Germantown, MD) and the other half was used to evaluate the histology and the apoptosis. We had the following groups: Non-Irradiated Tissue, Irradiated Tissue with 12 Gy; Irradiated Tissue with 12 Gy pretreated with N-acetylcysteine (ACS); Irradiated Tissue with 12 Gy pretreated with the Traditional Chinese Medicine (TCM) Qingre-Liyan decoction; and Irradiated Tissue with 12 Gy pretreated with 50:50 w/w ACS:TCM (AT) Group 1: Human Prirmary 3-D Cultures of Human Keratinocytes were irradiated with 12 Gy; Group 2: Human Prirmary 3-D Cultures of Human Keratinocytes were pretereated with N-acetylcysteine (ACS) and then irradiated with 12 Gy; Human Prirmary 3-D Cultures of Human Keratinocytes were pretreated with the Traditional Chinese Medicine (TCM), Qingre-Liyan Decostion and then irradiated with 12 Gy; Human Prirmary 3-D Cultures of Human Keratinocytes were pretreated with a 50:50 w/w mixture of ACS:TCM (AT) and then irradiated with 12 Gy. Each sample was done in triplicate.

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