Project description:To define retinoic acid-responsive transcriptional programs in the intestinal stem cells, we performed RNA sequencing on stem cell-enriched intestinal organoids following 24-hour retinoic acid treatment. This dataset provides a resource for examining gene expression changes associated with retinoic acid signaling in intestinal stem cell-enriched epithelial cultures.
Project description:We inflicted TBI to wildetype (wt) mice in order to establish whether the anti-inflammatory agent cyclophosphamide can be used therapeutically. Cyclophosphamide was found to regulate distinct inflammatory cells such as activated microglia separate from invading phagocytes and dendritic cells. Cyclophosphamide postinjury selectively reduces antigen-presenting dendritic cells. Findings show feasibility of drug development to interfere with brain inflammation.
