Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gut Microbiota Orchestrates Energy Homeostasis during Cold

ABSTRACT: Gut Microbiota Orchestrates Energy Homeostasis during Cold

PROVIDER: PRJNA299602 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR2727630.fastq.gz	Fastqsanger.gz
	SRR2727631.fastq.gz	Fastqsanger.gz
	SRR2727632.fastq.gz	Fastqsanger.gz
	SRR2727633.fastq.gz	Fastqsanger.gz
	SRR2727634.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 108

Similar Datasets

Gut Microbiota Orchestrates Energy Homeostasis during Cold [RNA-Seq]

Project description:Microbial functions in the host physiology are a result of co-evolution between microbial communities and their hosts. Here we show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase the insulin sensitivity of the host, and enable complete tolerance to cold partly by promoting the white fat browning, leading to increased energy expenditure and fat loss. During prolonged cold however, the body weight loss is attenuated, caused by adaptive mechanisms maximising caloric uptake and increasing intestinal, villi and microvilli lengths. This increased absorptive surface is promoted by the cold microbiota - effect that can be diminished by co-transplanting the most downregulated bacterial strain from the Verrucomicrobia phylum, Akkermansia muciniphila, during the cold microbiota transfer. Our results demonstrate the microbiota as a key factor orchestrating the overall energy homeostasis during increased demand.

2015-12-03 | GSE74157 | GEO

Gut Microbiota Orchestrates Energy Homeostasis during Cold [16S rRNA gene V4-region miSeq]

2015-12-03 | GSE74227 | GEO

Gut Microbiota Orchestrates Energy Homeostasis during Cold

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-12-03 | GSE74228 | GEO

Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning

Project description:Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning

2023-10-24 | PXD046337 |

Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis

Project description:Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis

| PRJNA880299 | ENA

Mus musculus

Project description:Gut Microbiota Orchestrates Energy Homeostasis during Cold [RNA-Seq]

| PRJNA299190 | ENA

Endothelial Pd1 orchestrates cerebrovasculature homeostasis and oligodendrogenesis during brain development

Project description:Endothelial Pd1 orchestrates cerebrovasculature homeostasis and oligodendrogenesis during brain development

| PRJNA1110160 | ENA

Cardiolipin Synthesis Governs Systemic Energy Homeostasis through Thermogenic Fat Mitochondria

Project description:Here we show that synthesis of the mitochondrial phospholipid cardiolipin is an indispensable driver of thermogenic fat function. Cardiolipin biosynthesis is robustly induced in brown and beige adipose upon cold exposure. Mimicking this response by overexpressing cardiolipin synthase (Crls1) enhances energy consumption in mouse and human adipocytes. Crls1 deficiency diminishes mitochondrial uncoupling in brown and beige adipocytes and elicits a nuclear transcriptional response through ER stress-mediated retrograde communication. Cardiolipin depletion in brown and beige fat abolishes adipose thermogenesis and glucose uptake and renders animals strikingly insulin resistant. We further identify a rare human CRLS1 variant associated with insulin resistance and show that adipose CRLS1 levels positively correlate with insulin sensitivity. Thus, adipose cardiolipin is a powerful regulator of organismal energy homeostasis through thermogenic fat bioenergetics.

2018-07-19 | GSE110297 | GEO

Stem cell competition orchestrates skin homeostasis and ageing

Project description:Stem cell competition orchestrates skin homeostasis and ageing

| PRJNA438288 | ENA

Core transcription regulatory circuitry orchestrates stratified epithelial homeostasis

Project description:Core transcription regulatory circuitry orchestrates stratified epithelial homeostasis

| PRJNA657244 | ENA