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Mus musculus

ABSTRACT: RNA-Seq of subcutaneous inguinal white fat of Hlx transgenic mice and littermate controls.

PROVIDER: PRJNA312769 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3181010.fastq.gz	Fastqsanger.gz
	SRR3181011.fastq.gz	Fastqsanger.gz
	SRR3181012.fastq.gz	Fastqsanger.gz
	SRR3181013.fastq.gz	Fastqsanger.gz
	SRR3181014.fastq.gz	Fastqsanger.gz

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RNA-Seq of subcutaneous inguinal white fat of Hlx transgenic mice and littermate controls.

Project description:RNA-Seq of subcutaneous inguinal white fat of Hlx transgenic mice and littermate controls.

2017-08-11 | GSE78143 | GEO

Interaction between PPARγ and mTORC1 in the regulation of inguinal white adipose tissue transcriptome

Project description:Purpose: To investigate the involvement of mTORC1 as a mediator of the actions of the PPARγ ligand rosiglitazone in subcutaneous inguinal white adipose tissue transcriptome; Methods: Mice bearing regulatory associated protein of mTOR (Raptor) deletion and therefore mTORC1 deficiency exclusively in adipocytes (adiponectin Cre recombinase) and littermate controls were fed a high-fat diet supplemented or not with the PPARγ agonist rosiglitazone (30 mg/kg/day) for 8 weeks and evaluated for inguinal white adipose tissue transcriptome (Rnaseq); Results: 3,2425 genes had their correspondent mRNA levels altered by either adipocyte Raptor deficiency or rosiglitazone administration or their combination. Among those, 408 genes modulated by rosiglitazone required mTORC1. Conclusion: PPARγ and mTORC1 are essential partners in the regulation of a cluster of genes in inguinal white adipose tissue.

2022-02-01 | GSE166988 | GEO

RNA-sequencing of inguinal white adipose tissue (iWAT) from kynurenine 3-monooxygenase (Kmo) knockout mice and wild-type littermates on chow and high-fat diets.

Project description:To investigate if chronically elevated circulating kynurenic acid (KYNA) and reduced quinolinic acid (QUIN) levels affect whole-body energy metabolism, we used a knockout-first gene targeting strategy to eliminate Kmo gene expression in mice. We conducted a series of metabolic assessments on male and female mice fed either a chow or high-fat diet (HFD) and performed RNA-sequencing on the inguinal white adipose tissue (iWAT) from male Kmo-defficient mice and their wild-type littermate controls on chow and high-fat diets.

2025-02-08 | GSE277692 | GEO

Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population

Project description:Here we provide scRNAseq data from the stromal vascular fraction of adult (8 weeks) and adolescent (2 weeks) murine inguinal subcutaneous white adipose tissue. This allows studying cellular composition and cellular heterogeneity within subcutaneous fat.

2021-01-07 | GSE164350 | GEO

Expression data from multiple mouse adipose depots

Project description:Comparing gene expression profiles of murine subcutaneous vs. visceral adipose tissue. Gene expression was analyzed in two subcutaneous depots (inguinal and axillary) and two visceral depots (epididymal and mesenteric) from male C57Bl/6 mice. 4 samples were analyzed as two groups: inguinal and axillary (subcutaneous) and epididymal and mesenteric (visceral). Each sample was derived by pooling RNA from the relevant fat depot from 3 age-matched, male C57Bl6 mice.

2014-01-16 | E-GEOD-53307 | biostudies-arrayexpress

Mus musculus

Project description:Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice

| PRJNA356754 | ENA

Expression data from the visceral adipose tissues of Lgr4 mutant (KO) and wild-type (WT) mice

Project description:Lgr4 acts as a key factor to regulate energy expenditure and body weight. Visceral fat (epidydimal white adipose tissue, eWAT) show a significant reduction in Lgr4 mutant mice than littermate controls, especially in high-fat diet (HFD) condition. A white-to-brown fat switch of eWAT in Lgr4 mice was reported by our group. However, the whole-genome expression profile of eWAT has not been comphrehensively studied. We used microarrays to reveal the potential novel factors underlying browning process.

2022-01-28 | GSE195570 | GEO

Impact of UCP1 and FGF21 for the development of diet-induced obesity at standard housing temperatures

Project description:Global RNA sequencing analysis of brown fat (BAT), inguinal white fat (iWAT), liver and muscle (quadriceps) of high-fat diet fed WT, FGF21 KO, UCP1 KO and UCP1/FGF21 double KO mice.

2019-11-05 | GSE122167 | GEO

Single cell sequencing of Tomato+ cells in Inguinal White Fat from Prrx1-CreERT;Tomato mice with the treatment of Tamoxifen for 3 days

Project description:We report single-cell RNA-seq reveals gene signatures associated with Inguinal White Fat from adult Prrx1-CreERT;Tomato mice.

2020-06-03 | GSE115298 | GEO

White adipose tissue browning in the R6/2 mouse model of Huntington's disease

Project description:We investigated gene expression signatures in subcutaneous inguinal adipose tissue obtained from wild type and R6/2 mice with the aim to identify gene expression changes and signalling pathway alterations in adipose tissue relevant to HD. Gene expression was assessed using Affymetrix GeneChipÂ® Mouse Gene 2.0 ST Array. Target genes were technically validated using real-time quantitative PCR. 12 subcutaneous inguinal white adipose tissue samples were analyzed by affymetrix: 6 wild-type samples; 6 R6/2 mouse samples.

2016-07-28 | E-GEOD-79711 | biostudies-arrayexpress

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