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Mus musculus

ABSTRACT: Identification of in vivo binding sites for YY2.

PROVIDER: PRJNA320088 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3467173.fastq.gz	Fastqsanger.gz
	SRR3467174.fastq.gz	Fastqsanger.gz

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Identification of in vivo binding sites for YY2.

Project description:We report the application of next generation sequencing for high-throughput profiling of Yin Yang 2 (YY2) binding sites in mammalian Trophectoderm Stem cells. Sequencing of chromatin obtained in chromatin-immunoprecipitation (ChIP) assays carried out with αYY2 serum yielded over ten million sequence reads. Peak finding allowed us allowed us to identify a limited number of chromatin targets for YY2. Putative binding sites were validated in regular ChIP assays and gene expression of a few genes nearby was altered in the absence of Yy2. This study provides a framework to understand the role of YY2 in diverse mammalian cell populations.

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