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Mus musculus

ABSTRACT: Tbet regulates the transcriptional programming of Be1 B cells.

PROVIDER: PRJNA326750 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3715300_1.fastq.gz	Fastqsanger.gz
	SRR3715300_2.fastq.gz	Fastqsanger.gz
	SRR3715301_1.fastq.gz	Fastqsanger.gz
	SRR3715301_2.fastq.gz	Fastqsanger.gz
	SRR3715302_1.fastq.gz	Fastqsanger.gz

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Tbet regulates the accessible chromatin of Be1 B cells

Project description:To investigate the role of Tbet in B cell differentiation to "effector-like" antibody secreting cells (ASC's) we utilized an ex vivo culture system to differentiate B cells in the presence of Th1 (Be1) or Th2 (Be2) polarized T cells. To determine the role of Tbet in Be1 cell differentiation we performed ATAC-seq on Wt Be1 and Tbet negative (TbetNeg) Be1 cells and Wt Be2 and Tbet negative (TbetNeg) Be2 cells. Collectively, these data show that T-bet serves as master regulator for the Be1 cell fate and is required to program chromatin accessibility during ASC differentiation in Be1 cells.

2019-04-29 | GSE118984 | GEO

Tbet regulates the transcriptional programming of Be1 B cells.

Project description:To investigate the role of Tbet in B cell differentiation to "effector-like" antibody secreting cells (ASC's) we utilized an ex vivo culture system to differentiate B cells (Be1 cells) in the presence of Th1 polarized T cells. To determine the role of Tbet in Be1 cell differentiation we performed RNA-seq on Wt Be1 and Tbet negative (TbetNeg) Be1 cells. Collectively, these data show that T-bet serves as master regulator for the Be1 cell fate and is required for induction of genes required for ASC differentiation in Be1 cells.

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Tbet regulates the accessible chromatin of Be1 B cells

Project description:Tbet regulates the accessible chromatin of Be1 B cells

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Project description:Expression data from Tbet+ and Tbet- Memory B cells

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