Project description:DNA methylation profiling of Prefrontal Cortex of male rats at postnatal day 62 whose mothers were exposed to restraint stress from gestation day 14 until delivery
Project description:DNA methylation profiling of Prefrontal Cortex of male rats at postnatal day 62 whose mothers were exposed to restraint stress from gestation day 14 until delivery The groups consist of 1. Control rats (Ctrl) 2. Prenatally stressed rats (PNS)
Project description:To unravel the gene expression changes during postnatal prefrontal cortex development, RNA-seq was performed in the rat medial prefrontal cortex at five time points from early life to adulthood (postnatal day 8, 14, 21, 35 and 70) and differential expression of protein-coding genes, lincRNAs and alternative exons was analyzed. A switch from neuronal network development to maintenance during postnatal rat prefrontal cortex development was shown.
Project description:To investigate how exposure to morphine during the prenatal and early postnatal period affects the offspring prefrontal cortex in a mouse model We performed gene expression profiling analysis using data obtained from RNA-seq of offspring prefrontal cortical brain samples at postnatal day 21
Project description:Autism spectrum disorder (ASD) affects approximately 2.8% of the population and is characterized by substantial genetic heterogeneity. Bulk RNA sequencing was performed on prefrontal cortex tissue from Tbr1+/K228E heterozygous (HT) and wild-type (WT) mice. Animals were analyzed at postnatal day 40 (P40) following three weeks of treatment with fluoxetine or lithium. Both male and female mice were included. Dissected prefrontal cortex tissue was used for RNA extraction and sequencing.
Project description:Autism spectrum disorder (ASD) affects approximately 2.8% of the population and is characterized by substantial genetic heterogeneity. Bulk RNA sequencing was performed on prefrontal cortex tissue from Dyrk1a+/I48X heterozygous (HT) and wild-type (WT) mice. Animals were analyzed at postnatal day 40 (P40) following three weeks of treatment with fluoxetine or lithium. Both male and female mice were included. Dissected prefrontal cortex tissue was used for RNA extraction and sequencing.
Project description:Autism spectrum disorder (ASD) affects approximately 2.8% of the population and is characterized by substantial genetic heterogeneity. Bulk RNA sequencing was performed on prefrontal cortex tissue from Adnp heterozygous (HT) and wild-type (WT) mice. Animals were analyzed at postnatal day 40 (P40) following three weeks of treatment with fluoxetine or lithium. Both male and female mice were included. Dissected prefrontal cortex tissue was used for RNA extraction and sequencing.
Project description:Autism spectrum disorder (ASD) affects approximately 2.8% of the population and is characterized by substantial genetic heterogeneity. Bulk RNA sequencing was performed on prefrontal cortex tissue from PTEN KI heterozygous (HT) and wild-type (WT) mice. Animals were analyzed at postnatal day 40 (P40) following three weeks of treatment with fluoxetine or lithium. Both male and female mice were included. Dissected prefrontal cortex tissue was used for RNA extraction and sequencing.
Project description:To understand the consequences of chronic exposure to fluoxetine during postnatal life on global transcriptional changes withing the rat medial prefrontal cortex in adulthood. To understand the consequences of chronic exposure to fluoxetine during postnatal life on global transcriptional changes withing the rat medial prefrontal cortex in adulthood.
Project description:This SuperSeries is composed of the following subset Series: GSE17757: Gene expression data from primate postnatal brain in prefrontal cortex: time course GSE18012: miRNA expression data from human postnatal brain in prefrontal cortex: time course GSE18013: miRNA expression data from rhesus macaque postnatal brain in prefrontal cortex: time course Refer to individual Series
