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Homo sapiens

ABSTRACT: Gene expression data from MGH-U3 following FGFR3 knock-down using FGFR3 siRNAs

OTHER RELATED OMICS DATASETS IN: GSE84733

PROVIDER: PRJNA330970 | ENA |

REPOSITORIES: ENA

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Homo sapiens

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Gene expression data from MGH-U3 following FGFR3 knock-down using FGFR3 siRNAs

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Chromatin accessibility profile at single cell level of different phenotypic tumors derived from the human non-muscle invasive bladder carcinoma cell line, MGH-U3

Project description:To understand the genetic mechanisms by which IGFBP5 regulates aggressive progression and squamous traits, we performed whole-exome sequencing (WES) on three distinct cell lines: CTR-MGH-U3-LT, UCSD-MGH-U3-LT, and MP-MGH-U3-LT. WES revealed no mutations in IGFBP5, suggesting that its regulatory role may involve epigenetic mechanisms. We next sought to perform single-cell ATAC-seq to investigate a potential epigenetic mechanism underlying IGFBP5 regulated squamous traits and aggressiveness.

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Gene expression data from MGH-U3, RT112 and UM-UC-5 following TYRO3 knock-down

Project description:To better understand the molecular mechanisms underlying TYRO3 oncogenic activity in bladder carcinomas, we made use of MGH-U3, RT112 and UM-UC-5 cell lines, which were derived from a human bladder tumor and endogenously expressed the Tyro3 protein, the growth and transformation of these cell lines being dependent on Tyro3. We carried out a gene expression analysis using Affymetrix DNA arrays in this cell line treated or not withTYRO3 siRNAs.

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Single-cell data for FGFR3-driven gene regulatory network analysis reveals a pro-tumoral role for p63 in luminal bladder tumors

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