Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rattus norvegicus

ABSTRACT: Genome wide identification of gene sets involved in the regulation of hypothalamic pubertal development

PROVIDER: PRJNA368747 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5204190.fastq.gz	Fastqsanger.gz
	SRR5204200.fastq.gz	Fastqsanger.gz
	SRR5204181.fastq.gz	Fastqsanger.gz
	SRR5204191.fastq.gz	Fastqsanger.gz
	SRR5204182.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 20

Similar Datasets

Rattus norvegicus

Project description:Genome wide identification of chromatin modifications in the hypothalamus during pubertal development

| PRJNA377859 | ENA

Rattus norvegicus

Project description:Transcriptome of normal mammary glands of Sprague-Dawley rats at six stages of development: pre-pubertal, peri-pubertal, pubertal, lactation, adult parous and age-matched nulliparous

| PRJNA345385 | ENA

Chromatin accessibility in mouse hypothalamic arcuate nucleus in puberty onset

Project description:To better understand the epigenetic mechanism underlying pubertal onset, the hypothalamic genome-wide chromatin accessibility patterns in mouse arcuate nucleus at early and late pubertal stages were explored. Female mice have been widely used in multiple studies on pubertal development as they present the similar molecular behaviors in HPG axis and stable cycles of menstrual calendar like human. Hypothalamic ARC underwent a huge epigenetic and genetic reprogramming to adapt to the response and feedback on sexual hormones during the stages of early pubertal (2-5-week of age) and late puberty (5-8-week of age) . We harvested 4- and 8-week hypothalamic ARC and employed ATAC-seq on a genome-wide scale. Combined with previous RRBS, RRHP and RNA-seq, the connections between DNA (hydroxyl)methylation in retroelements and gene expression were studied, emphasizing the importance of epigenetic alterations in regulating transcription in puberty onset.

2021-04-02 | E-MTAB-10263 | biostudies-arrayexpress

Transcriptome and DNA (hydro)methylation in mouse hypothalamic arcuate nucleus in puberty onset

Project description:To better understand the epigenetic mechanism underlying pubertal onset, the hypothalamic genome-wide DNA methylation and hydroxymethylation patterns as well as the transcription profiles in mouse arcuate nucleus at early and late pubertal stages were explored. Female mice have been widely used in multiple studies on pubertal development as they present the similar molecular behaviors in HPG axis and stable cycles of menstrual calendar like human. Hypothalamic ARC underwent a huge epigenetic and genetic reprogramming to adapt to the response and feedback on sexual hormones during the stages of early pubertal (2-5-week of age) and late puberty (5-8-week of age) . We harvested 4- and 8-week hypothalamic ARC and employed RNA-seq, reduced representation bisulfite sequencing (RRBS) and hydroxymethylation profiling (RRHP) on a genome-wide scale. We identified a large number of differential expressed genes (DEGs) and differential 5(h)mC signals across the whole genome. We discovered novel connections between DNA (hydroxyl)methylated modification and gene expression, emphasizing the importance of epigenetic alterations in regulating transcription in puberty onset.

2020-08-21 | E-MTAB-9421 | biostudies-arrayexpress

Transcriptome and DNA (hydro)methylation in mouse hypothalamic arcuate nucleus in puberty onset.

2020-08-20 | E-MTAB-9420 | biostudies-arrayexpress

Rattus norvegicus

Project description:Genome wide expression analysis of the Hypothalamic control of Mammalian Puberty

| PRJNA167509 | ENA

Radiation effects on gene expression in rat testes (Rattus norvegicus)

Project description:Analysis of LBNF1 rat testes from controls, containing both somatic and all germ cell types and from irradiated rats in which all cells germ cells except type A spermatgogonia are eliminated. Results provide insight into distinguishing germ and somatic cell genes and identification of somatic cell genes that are upregulated after irradiation.

2009-09-30 | GSE15223 | GEO

Rattus norvegicus

Project description:Promoter methylation analysis in rat Pubertal Hypothalamus

| PRJNA168090 | ENA

Molecular and Structural Bases of Hypothalamic Puberty

Project description:To compare the global profile of hypothalamic gene expression in agonadal male Rhesus Monkeys before and after reactivation of the pulsatile GnRH release during the pubertal phase of development. 20 Samples looking at Cortex and Mediobasal hypothalamus in 3 stages of Rhesus Monkeys (early pubertal, late juvenile, and late pubertal).

2014-12-20 | E-GEOD-64396 | biostudies-arrayexpress

Rattus norvegicus

Project description:Transcriptome analysis of hypothalamuses from prepubertal and pubertal rats

| PRJNA382254 | ENA