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Two distinct myeloid subsets at the term human fetal-maternal interface

ABSTRACT: Two distinct myeloid subsets at the term human fetal-maternal interface

PROVIDER: PRJNA412078 | ENA |

REPOSITORIES: ENA

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Sexually dimorphic crosstalk at the maternal-fetal interface

Project description:The first trimester is a critical window of maternal-fetal communication for pregnancy. RNA-sequencing of matched maternal decidua (4) and placenta (4) identified 91 sexually dimorphic receptor-ligand pairs across the maternal-fetal interface, 32 in females and 59 in males.

2020-08-20 | GSE131874 | GEO

Two distinct myeloid subsets at the term human fetal-maternal interface

Project description:The subsets of immune cells within the human placenta are incompletely described. We used microarray to determine the transcriptional differences between two myeloid subsets in the term human placenta.

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Methylome of Fetal and Maternal Monocytes and Macrophages at the Feto-Maternal Interface

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Methylome of Fetal and Maternal Monocytes and Macrophages at the Feto-Maternal Interface

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2011-11-15 | E-GEOD-31680 | biostudies-arrayexpress

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Sexually dimorphic crosstalk at the maternal-fetal interface

Project description:Sexually dimorphic crosstalk at the maternal-fetal interface

| PRJNA545159 | ENA

Sexually dimorphic crosstalk at the maternal-fetal interface

Project description:Sexually dimorphic crosstalk at the maternal-fetal interface

| PRJNA545158 | ENA

Sexually dimorphic crosstalk at the maternal-fetal interface

Project description:Sexually dimorphic crosstalk at the maternal-fetal interface

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Sexually dimorphic crosstalk at the maternal-fetal interface

Project description:The first trimester is a critical window of maternal-fetal communication for pregnancy. Using single cell RNA-sequencing to dissect placenta heterogeneity, we identified five major cell types (trophoblasts, stromal cells, hofbauer cells, antigen presenting cells and endothelial cells). We identified seven unique trophoblast subclusters, including new subtypes that transition into the terminal cell types, extra-villous trophoblasts and syncytiotrophoblasts. As fetal sex impacts pregnancy, we analyzed sex differences in each cell type and identified differences in immune cell function. TGFβ1, β-estradiol, and dihydrotestosterone emerge as upstream regulators of sexually dimorphic genes in a cell type specific manner. Thus, the fetal contribution at the maternal-fetal interface is cell and sex specific.

2020-08-20 | GSE131696 | GEO

Two Distinct Myeloid Subsets at the Term Human Fetal-Maternal Interface.

Project description:During pregnancy, immune cells infiltrate the placenta at different stages of fetal development. NK cells and macrophages are the most predominant cell types. These immune cells play pleiotropic roles, as they control spiral artery remodeling to ensure appropriate blood supply and maintain long-term tolerance to a true allograft; yet, they must be able to mount appropriate immune defenses to pathogens that may threaten the fetus. Whether the same cell type accomplishes all these tasks or if there are dedicated subsets remains controversial. Here, we identify and characterize two distinct subsets of myeloid cells that differ in their pro-inflammatory/regulatory capacity. While one subset predominantly produces the immune-modulating cytokine IL-10, the second subset has superior capacity to secrete pro-inflammatory mediators, such as IL-1β and IL-6. The putative regulatory myeloid cells also express high levels of inhibitory receptors and their ligands, including programmed cell death 1 (PD1) ligands. Importantly, a large fraction of CD8 and CD4 cells in normal term human placenta are PD1 positive, suggesting that the PD1/PD1 ligands axis might be critical to maintain tolerance during pregnancy.

| S-EPMC5662895 | biostudies-literature

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