Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Sexually dimorphic crosstalk at the maternal-fetal interface

ABSTRACT: Sexually dimorphic crosstalk at the maternal-fetal interface

PROVIDER: PRJNA544522 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Sexually dimorphic crosstalk at the maternal-fetal interface

Project description:Sexually dimorphic crosstalk at the maternal-fetal interface

| PRJNA545159 | ENA

Sexually dimorphic crosstalk at the maternal-fetal interface

Project description:Sexually dimorphic crosstalk at the maternal-fetal interface

| PRJNA545158 | ENA

Sexually dimorphic crosstalk at the maternal-fetal interface

Project description:The first trimester is a critical window of maternal-fetal communication for pregnancy. RNA-sequencing of matched maternal decidua (4) and placenta (4) identified 91 sexually dimorphic receptor-ligand pairs across the maternal-fetal interface, 32 in females and 59 in males.

2020-08-20 | GSE131874 | GEO

Sexually dimorphic crosstalk at the maternal-fetal interface

Project description:The first trimester is a critical window of maternal-fetal communication for pregnancy. Using single cell RNA-sequencing to dissect placenta heterogeneity, we identified five major cell types (trophoblasts, stromal cells, hofbauer cells, antigen presenting cells and endothelial cells). We identified seven unique trophoblast subclusters, including new subtypes that transition into the terminal cell types, extra-villous trophoblasts and syncytiotrophoblasts. As fetal sex impacts pregnancy, we analyzed sex differences in each cell type and identified differences in immune cell function. TGFβ1, β-estradiol, and dihydrotestosterone emerge as upstream regulators of sexually dimorphic genes in a cell type specific manner. Thus, the fetal contribution at the maternal-fetal interface is cell and sex specific.

2020-08-20 | GSE131696 | GEO

Sexually Dimorphic Crosstalk at the Maternal-Fetal Interface.

Project description:ContextCrosstalk through receptor ligand interactions at the maternal-fetal interface is impacted by fetal sex. This affects placentation in the first trimester and differences in outcomes. Sexually dimorphic signaling at early stages of placentation are not defined.ObjectiveInvestigate the impact of fetal sex on maternal-fetal crosstalk.DesignReceptors/ligands at the maternal-fetal surface were identified from sexually dimorphic genes between fetal sexes in the first trimester placenta and defined in each cell type using single-cell RNA-Sequencing (scRNA-Seq).SettingAcademic institution.SamplesLate first trimester (~10-13 weeks) placenta (fetal) and decidua (maternal) from uncomplicated ongoing pregnancies.Main outcome measuresTranscriptomic profiling at tissue and single-cell level; immunohistochemistry of select proteins.ResultsWe identified 91 sexually dimorphic receptor-ligand pairs across the maternal-fetal interface. We examined fetal sex differences in 5 major cell types (trophoblasts, stromal cells, Hofbauer cells, antigen-presenting cells, and endothelial cells). Ligands from the CC family chemokine ligand (CCL) family were most highly representative in females, with their receptors present on the maternal surface. Sexually dimorphic trophoblast transcripts, Mucin-15 (MUC15) and notum, palmitoleoyl-protein carboxylesterase (NOTUM) were also most highly expressed in syncytiotrophoblasts and extra-villous trophoblasts respectively. Gene Ontology (GO) analysis using sexually dimorphic genes in individual cell types identified cytokine mediated signaling pathways to be most representative in female trophoblasts. Upstream analysis demonstrated TGFB1 and estradiol to affect all cell types, but dihydrotestosterone, produced by the male fetus, was an upstream regulator most significant for the trophoblast population.ConclusionsMaternal-fetal crosstalk exhibits sexual dimorphism during placentation early in gestation.

| S-EPMC7571453 | biostudies-literature

Sexually dimorphic crosstalk at the maternal-fetal interface

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-08-20 | GSE131875 | GEO

Sexually dimorphic gene expression responses of bovine embryos to the maternal microenvironment

Project description:This study investigated the sexual dimorphic gene expression patterns of day 13 embryos developed in Holsteins Frisian cows and heifers. Accordingly, embryos developed in the cows exhibited sexually dimorphic expression of genes associated with steroid biosynthesis and metabolism as well as genes associated with the formation of the primary germ layer whereas those developed in heifers sexually dimorphic expression of genes involved in developmental processes, gonadal development or female sex differentiation, and transmembrane transports. This result may partly explain the possible causes of a skewed sex ratio during development and at birth.

2025-04-02 | GSE276275 | GEO

Sex Estimation Using Sexually Dimorphic Amelogenin Protein Fragments in Human Enamel

Project description:Sex estimation of human remains from demineralized blocks of tooth enamel by liquid chromatography tandem mass spectrometry (LC- MS/MS) and proteomic analysis of sexually dimorphic amelogenin peptides. The detection of the Y-isoform of amelogenin is used to estimate male sex. The combined signal intensity of the sexually dimorphic peptides from each samples of known sex is used to establish a statistical framework for the estimation of the female sex probability.

2018-11-29 | PXD009781 | Pride

Effect of somatostatin knockout on sexually dimorphic hepatic gene expression

Project description:The liver is one of the most sexually dimorphic organs as measured by gene expression differences. About 80% of the sexually dimorphic genes are known to be regulated by growth hormone (GH). Somatostatin (SST) inhibits the release of GH. We generated a SST-knockout mouse and analyzed the hepatic gene expression changes in both sexes.

2014-12-01 | GSE56520 | GEO

Sexually dimorphic ozone-induced changes in fetal rat hypothalamus

Project description:Sexually dimorphic ozone-induced changes in fetal rat hypothalamus

| PRJNA659294 | ENA