Sexually Dimorphic Crosstalk at the Maternal-Fetal Interface.

ABSTRACT:

Context

Crosstalk through receptor ligand interactions at the maternal-fetal interface is impacted by fetal sex. This affects placentation in the first trimester and differences in outcomes. Sexually dimorphic signaling at early stages of placentation are not defined.

Objective

Investigate the impact of fetal sex on maternal-fetal crosstalk.

Design

Receptors/ligands at the maternal-fetal surface were identified from sexually dimorphic genes between fetal sexes in the first trimester placenta and defined in each cell type using single-cell RNA-Sequencing (scRNA-Seq).

Setting

Academic institution.

Samples

Late first trimester (~10-13 weeks) placenta (fetal) and decidua (maternal) from uncomplicated ongoing pregnancies.

Main outcome measures

Transcri

SUBMITTER: Sun T 

PROVIDER: S-EPMC7571453 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature