Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction.

ABSTRACT:

Background

Current methods fail to accurately predict women at greatest risk of developing fetal growth restriction (FGR) or related adverse outcomes, including stillbirth. Sexual dimorphism in these adverse pregnancy outcomes is well documented as are sex-specific differences in gene and protein expression in the placenta. Circulating maternal serum microRNAs (miRNAs) offer potential as biomarkers that may also be informative of underlying pathology. We hypothesised that FGR would be associated with an altered miRNA profile and would differ depending on fetal sex.

Methods

miRNA expression profiles were assessed in maternal serum (> 36 weeks' gestation) from women delivering a severely FGR infant (defined as an individualised birthweight centile (IBC) < 3rd) and matched cont

SUBMITTER: Baker BC 

PROVIDER: S-EPMC8597318 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature