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MiRNA Profiling of Exosomes from Spontaneous Hypertensive Rats by Next-Generation Sequencing

ABSTRACT: miRNA Profiling of Exosomes from Spontaneous Hypertensive Rats by Next-Generation Sequencing

PROVIDER: PRJNA416325 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6234940.fastq.gz	Fastqsanger.gz
	SRR6234950.fastq.gz	Fastqsanger.gz
	SRR6234941.fastq.gz	Fastqsanger.gz
	SRR6234942.fastq.gz	Fastqsanger.gz
	SRR6234943.fastq.gz	Fastqsanger.gz

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miRNA Profiling of Exosomes from Spontaneous Hypertensive Rats by Next-Generation Sequencing

Project description:The role and miRNA expression profile of exosomes in hypertension remain largely unknown, therefore, next generation sequencing was used to define the miRNA expression profile of plasma exosomes in spontaneously hypertensive rats (SHRs), the most widely used animal model of human essential hypertension, and their controls, normotensive Wistar-Kyoto rats (WKYs). Results revealed that percentages of miRNA in the total small RNA isolated from WKYs and SHRs were not significantly different. Twenty-seven miRNAs were significantly differentially expressed (DE) between WKY and SHR exosomes, among which 23 were upregulated and 4 were downregulated in SHR exosomes compared with WKY exosomes. Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis of top 10 DE miRNAs identified hypertension-specific target genes/signaling pathways. In conclusion, our findings indicate the selective packing of miRNA cargoes into exosomes under hypertensive status, while facilitating the development of potential targets for the diagnosis, prevention and treatment of hypertension.

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Microarray analysis of aortic tissue from different rat hypertensive models

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Project description:Our previous findings suggest that the nucleus of the solitary tract (NTS), a pivotal region for regulating the set-point of arterial pressure, exhibits abnormal inflammation in pre-hypertensive and spontaneously hypertensive rats (SHRs) together with elevated anti-apoptotic and low apoptotic factor levels compared with that of normotensive Wistar–Kyoto (WKY) rats. Whether this chronic condition affects neuronal growth and plasticity in the NTS remains unknown. To unveil the characteristics of the neurodevelopmental environment in the NTS of hypertensive rats, we investigated the gene expression profile of neurotrophins and their receptors in SHRs compared to that of normotensive rat WKY.

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