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Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis

ABSTRACT: Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis

PROVIDER: PRJNA428301 | ENA |

REPOSITORIES: ENA

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Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [Chordin]

Project description:Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [Chordin]

| PRJNA428289 | ENA

Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [Fam46a-MO1]

Project description:Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [Fam46a-MO1]

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Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [FAM46A-shRNA]

Project description:Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [FAM46A-shRNA]

| PRJNA428304 | ENA

Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [Chordin]

Project description:In early embryonic development, the organiser functions in multiple developmental processes, including neural induction, dorsoventral patterning of the mesoderm, and formation of the axial mesoderm. Chordin is a central molecule for the activity of the Spemann’s organiser and abundantly secreted from the Spemann’s organiser in Xenopus laevis. However, so far, a whole picture of the gene expression profile regulated by Chordin has not been examined. Here, we perform microarray analysis of chordin overexpression and identify fam46a as an upregulated gene. We demonstrate that fam46a is essential for Xenopus laevis early embryonic development as well as gene induction during cell differentiation in mammalian cell culture models. fam46a is preferentially expressed in tissues with high secretory ability. In Xenopus laevis, fam46a is required for normal neural tube closure and expression of epidermal markers, neural markers and mesodermal markers. In the human Caco-2 cell model, FAM46A is localised in the nucleus and cytoplasm, and regulates gene induction during cell differentiation. In the mouse intestinal organoid model, Fam46a is required for survival of organoids as well as enterocyte differentiation. These results indicate that fam46a is a regulator for gene expression in secretory cells during cell differentiation in early embryonic development and adult homeostasis.

2023-11-21 | GSE108684 | GEO

Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [FAM46A-shRNA]

2023-11-21 | GSE108691 | GEO

Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [Fam46a-MO1]

2023-11-21 | GSE108686 | GEO

ARID1A plays an important role in skin inflammation.

Project description:ARID1A plays an important role in skin inflammation.

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Altered mucosal homeostasis in mice lacking secretory antibodies

Project description:The mammalian gut is inhabited by a large and complex microbial community that lives in a mutualistic relationship with its host. Innate and adaptive mucosal defense mechanisms ensure a homeostatic relationship with this commensal microbiota. Secretory antibodies are generated from the active polymeric Ig receptor (pIgR)-mediated transport of IgA and IgM antibodies to the gut lumen and form the first line of adaptive immune defense of the intestinal mucosa. We probed mucosal homeostasis in pIgR knockout (KO) mice, which lack secretory antibodies. We found that in pIgR KO mice, colonic epithelial cells, the cell type most closely in contact with intestinal microbes, differentially expressed (>2-fold change) more than 200 genes compared with wild type mice, and upregulated the expression of anti-microbial peptides in a commensal-dependent manner. Detailed profiling of microbial communities based on 16S rRNA genes revealed differences in the commensal microbiota between pIgR KO and wild type mice. Furthermore, we found that pIgR KO mice showed increased susceptibility to dextran sulfate sodium (DSS)-induced colitis, and that this was driven by their conventional intestinal microbiota. In conclusion, secretory antibodies or the pIgR itself are required to maintain a stable commensal microbiota. In the absence of these humoral effector components, gut homeostasis is disturbed and the outcome of colitis significantly worsened. 4 groups: wild type mice treated with antibiotic (5 replicates), wild type mice left untreated (5 replicates), pIgR KO mice treated with antibiotic (6 replicates), and pIgR KO mice left untreated (6 replicates).

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