Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [FAM46A-shRNA]

ABSTRACT: Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [FAM46A-shRNA]

PROVIDER: PRJNA428304 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis

Project description:Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis

| PRJNA428301 | ENA

Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [FAM46A-shRNA]

Project description:In early embryonic development, the organiser functions in multiple developmental processes, including neural induction, dorsoventral patterning of the mesoderm, and formation of the axial mesoderm. Chordin is a central molecule for the activity of the Spemann’s organiser and abundantly secreted from the Spemann’s organiser in Xenopus laevis. However, so far, a whole picture of the gene expression profile regulated by Chordin has not been examined. Here, we perform microarray analysis of chordin overexpression and identify fam46a as an upregulated gene. We demonstrate that fam46a is essential for Xenopus laevis early embryonic development as well as gene induction during cell differentiation in mammalian cell culture models. fam46a is preferentially expressed in tissues with high secretory ability. In Xenopus laevis, fam46a is required for normal neural tube closure and expression of epidermal markers, neural markers and mesodermal markers. In the human Caco-2 cell model, FAM46A is localised in the nucleus and cytoplasm, and regulates gene induction during cell differentiation. In the mouse intestinal organoid model, Fam46a is required for survival of organoids as well as enterocyte differentiation. These results indicate that fam46a is a regulator for gene expression in secretory cells during cell differentiation in early embryonic development and adult homeostasis.

2023-11-21 | GSE108691 | GEO

Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [Chordin]

Project description:Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [Chordin]

| PRJNA428289 | ENA

Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [Fam46a-MO1]

Project description:Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [Fam46a-MO1]

| PRJNA428297 | ENA

Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [Chordin]

2023-11-21 | GSE108684 | GEO

Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis [Fam46a-MO1]

2023-11-21 | GSE108686 | GEO

ARID1A plays an important role in skin inflammation.

Project description:ARID1A plays an important role in skin inflammation.

| PRJNA966998 | ENA

RNA-binding activity plays an important role in MYC function

Project description:RNA-binding activity plays an important role in MYC function

| PRJNA1062072 | ENA

Peroxidase plays important roles in soybean tolerance to Al toxicity