Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide maps of H3K4me3 in C57BL6/J, DBA/2J, and BXD lines for male germ cells, hepatocytes, cardiomyocytes, and mouse ESCs

ABSTRACT: Genome-wide maps of H3K4me3 in C57BL6/J, DBA/2J, and BXD lines for male germ cells, hepatocytes, cardiomyocytes, and mouse ESCs

PROVIDER: PRJNA450402 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7010340.fastq.gz	Fastqsanger.gz
	SRR7010350.fastq.gz	Fastqsanger.gz
	SRR7010360.fastq.gz	Fastqsanger.gz
	SRR7010370.fastq.gz	Fastqsanger.gz
	SRR7010380.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 135

Similar Datasets

RNA-Seq of normal and infarcted DBA/2J and C57Bl6/N adult female hearts.

Project description:We have observed that DBA/2J and C57Bl6/N mice exhibit different responses to permanent coronary artery ligation, with mice in a C57 background having about a 14-fold increase in cardiomyocyte S-phase activity as compared to DBA mice. We mapped the responsible gene to the distal arm of Chromosome 3 in the C57 background. We then RNA-Seq analyses on hearts from normal and infarcted DBA and C57 mice, with the hope of identifying candidate genes within the region of interest on the distal arm of Chromosome 3 which are differentially expressed. These genes identified Tnni3k as a potential candidate contributing to the elevated S-phase phenotype.

2022-08-19 | GSE211380 | GEO

Decreased mRNA expression of malonyl-CoA decarboxylase emerges from an inborn error-like defect in the Mlycd gene of DBA/2J mice

Project description:Mlycd encodes malonyl-CoA decarboxylase (MCD), which is an enzyme that localizes in the cytosolic, mitochondrial, and peroxisomal compartments and catalyzes the conversion of malonyl-CoA into acetyl-CoA. Malonyl-CoA can be converted into malonylcarnitine (C3DC). Patients with an autosomal recessive defect of MCD and MCD KO mice have pronounced elevations of C3DC. Analysis of plasma C3DC levels in the BxD genetic reference population revealed increased levels in BxD strains that harbor the DBA/2J haplotype at the site of the Mlycd gene. RNA sequencing was performed on two samples of DBA/2J mouse livers and two C57BL/6J mouse livers. Decreased expression of Mlycd gene as well as intronic reads in intron 2 were observed in DBA/2J livers. Long-read sequecing of DBA/2J livers in the Mlycd region confirmed an intracisternal A-particle (IAP) retrotransposon in intron 2 of the DBA/2J Mlycd sequence. To confirm the causal nature of the variant, DBA/2J mice with and without the C57BL/6J variant of Mlycd spliced in were tested for products of MCD enzymatic activity, and the C57BL/6J variant was able to rescue the phenotype seen in the DBA/2J mice.

2024-10-26 | GSE186973 | GEO

COMPARATIVE PROTEOMICS ANALYSIS OF THE IRIDOCORNEAL REGION OF DBA/2J AND DBA/2J-Gpnmb+/SjJ MICE

Project description:In this study, we performed a comparative proteomics analysis of the iridocorneal region in DBA/2J and Gpnmb+ mice to gain deeper insight into the molecular mechanisms underlying IOP elevation following iris pigment dispersion/

2026-02-09 | PXD064786 | Pride

Expression profiling of liver tissue from C57BL6 x DBA strain

Project description:Expression profiling of liver tissue from 111 F2 female mice resulting from a cross between C57BL/6J and DBA/2J inbred mouse strains. Mice were feed a chow diet for 12 months followed by 4 months on an atherogenic high-fat, high-cholesterol diet. Parental and F2 mice were killed at 16 months of age. The livers were removed immediately and flash frozen for expression profiling. See Schadt, et al., Nature , Vol 422(6929):297-302 for details. Keywords = Genetics of Gene Expression Keywords = mouse Keywords = C57BL6 Keywords = DBA Keywords: repeat sample

2004-11-25 | GSE2008 | GEO

COMPARATIVE RNAseq ANALYSIS OF THE IRIDOCORNEAL REGION OF DBA/2J AND DBA/2J-Gpnmb+/SjJ MICE

Project description:We performed RNA sequencing analysis of the iridocorneal region in DBA/2J and Gpnmb+ mice to investigate alterations in gene expression and gain deeper insight into the molecular mechanisms underlying IOP elevation following iris pigment dispersion.

2026-03-10 | GSE299237 | GEO

Intra- and inter-individual genetic differences in gene expression (C57BL/6J vs DBA/2J)

Project description:Genetic variation is known to influence the amount of mRNA produced by a gene, but the effects in different tissues is unclear. We studied gene expression levels in whole brain, kidney or liver, comparing 8 week old, male C57BL/6J to DBA/2J mice. Genes differentially expressed due to genetic background in one tissue were not differentially expressed in other tissues, suggesting that genetic variation of gene expression is tissue specific in inbred mice. Data used in a comparison to the BXD panel of mice in GSE8355, GSE8356, GSE6621 and to SJL/J in GSE8358.

2005-05-18 | GSE2220 | GEO

RNA-Seq of normal and infarcted DBA/2J and C57Bl6/N adult female hearts.

Project description:RNA-Seq of normal and infarcted DBA/2J and C57Bl6/N adult female hearts.

| PRJNA870072 | ENA

Mus musculus strain:DBA/2J

Project description:Genome sequencing of the DBA/2J strain of mouse

| PRJNA33589 | ENA

Expression profiling of liver tissue from C57BL6 x DBA strain

2010-06-05 | E-GEOD-2008 | biostudies-arrayexpress

COMPARATIVE RNAseq ANALYSIS OF THE IRIDOCORNEAL REGION OF DBA/2J AND DBA/2J-Gpnmb+/SjJ MICE

Project description:COMPARATIVE RNAseq ANALYSIS OF THE IRIDOCORNEAL REGION OF DBA/2J AND DBA/2J-Gpnmb+/SjJ MICE

| PRJNA1273129 | ENA