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Establishment and characterization of prostate cancer organoids [array]

ABSTRACT: Establishment and characterization of prostate cancer organoids [array]

PROVIDER: PRJNA453752 | ENA |

REPOSITORIES: ENA

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Establishment and characterization of prostate cancer organoids

Project description:Establishment and characterization of prostate cancer organoids

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Establishment and characterization of prostate cancer organoids

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Establishment and characterization of prostate cancer organoids [RNA-seq]

Project description:Establishment and characterization of prostate cancer organoids [RNA-seq]

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Establishment and characterization of prostate cancer organoids [array]

Project description:Prostate cancer translational research has been hampered by the lack of comprehensive and tractable models that represent the genomic landscape of clinical disease. Metastatic castrate-resistant prostate cancer (mCRPC) patient derived xenografts (PDXs) recapitulate the genetic and phenotypic diversity of the disease. We sought to establish a representative, preclinical platform of PDX-derived organoids that is experimentally facile for high throughput and mechanistic analysis.

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Establishment and characterization of prostate cancer organoids [RNA-seq]

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Establishment and Characterization of Turtle Liver Organoids Provides a Potential Model to Decode their Unique Adaptations

Project description:Raw proteomic dataset from liver-derived organoids associated with Zdyrski et al. 2024 Communications Biology article (https://doi.org/10.1038/s42003-024-05818-1) entitled "Establishment and Characterization of Turtle Liver Organoids Provides a Potential Model to Decode their Unique Adaptations". Files 05032023_2.raw, 05032023_2_f2.raw, 05032023_2_f3.raw, ..... , 05032023_5_r3.raw correspond to samples F4-F15 from Chrysemys picta turtles, as described in the text.

2024-01-30 | PXD048455 | Pride

Establishment and Characterization of Turtle Liver Organoids Provides a Potential Model to Decode their Unique Adaptations

Project description:Raw proteomic dataset from liver-derived organoids associated with Zdyrski et al. 2024 Communications Biology article (https://doi.org/10.1038/s42003-024-05818-1) entitled "Establishment and Characterization of Turtle Liver Organoids Provides a Potential Model to Decode their Unique Adaptations". Files 05032023_1.raw, 05032023_1_r2.raw, and 05032023_1_r3.raw correspond to samples F1-F3 from Chelydra serpentina turtles as described in the text.

2024-01-30 | PXD048526 | Pride

Molecular characterization of neuroendocrine prostate cancer organoids and PDOX by RNA-seq

Project description:We report the generation and characterization of tumor organoids and PDOX derived from needle biopsies of metastatic lesions from neuroendocrine prostate cancer patients.

2018-06-22 | GSE112786 | GEO

Establishment, Characterization, and Tissue Comparison of Canine Pancreatic and Endometrial Organoids, Alongside Patient Matched Organoids

Project description:Organoids are 3-dimensional (3D) stem cell-derived cultures that offer a variety of technical advantages compared to traditional 2-dimensional (2D) cell cultures. Although murine models have proved useful in biomedical research, rodent models often fail to adequately mimic human physiology and disease progression, resulting in poor preclinical prediction of therapeutic drug efficacy and toxicity. An interesting alternative is to use the canine model in research, due to its numerous similarities to humans (shared environment, intact immune system, and development of civilization diseases). The use of canine organoids in drug testing and disease modeling has been limited by the number of models as well as the depth of characterization. Here, we report the establishment, maintenance, and molecular characterization of six adult-stem cell-derived canine organoid cell lines from endometrium, pancreas, urinary bladder, kidney, lung, and liver from two genetically related canines. The organoids of the canine endometrium and pancreas have not yet been described in the literature. Furthermore, scRNASeq was utilized on a subset of the organoids to identify organoid specific transcriptomic signatures including lung (SFTPC), pancreas (TFF3), kidney (GJB2), and bladder (UPK1A). In total, six tissues and organoid lines from each donor were characterized, allowing for a unique, multi-organ comparison between these two individuals and identification of specific cell types within the organoids.

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