Project description:Prostate cancer translational research has been hampered by the lack of comprehensive and tractable models that represent the genomic landscape of clinical disease. Metastatic prostate cancer patient-derived models recapitulate the genetic and phenotypic diversity of the disease.We sought to establish a representative, preclinical platform of patient-derived organoids that is experimentally facile for high throughput and mechanistic analysis.

2026-01-31 | GSE309847 | GEO

Establishment and characterization of prostate cancer organoids [array]

Project description:Prostate cancer translational research has been hampered by the lack of comprehensive and tractable models that represent the genomic landscape of clinical disease. Metastatic castrate-resistant prostate cancer (mCRPC) patient derived xenografts (PDXs) recapitulate the genetic and phenotypic diversity of the disease. We sought to establish a representative, preclinical platform of PDX-derived organoids that is experimentally facile for high throughput and mechanistic analysis.

2018-05-10 | GSE113709 | GEO

Establishment and characterization of prostate cancer organoids [RNA-seq]

Project description:Prostate cancer translational research has been hampered by the lack of comprehensive and tractable models that represent the genomic landscape of clinical disease. Metastatic castrate-resistant prostate cancer (mCRPC) patient derived xenografts (PDXs) recapitulate the genetic and phenotypic diversity of the disease. We sought to establish a representative, preclinical platform of PDX-derived organoids that is experimentally facile for high throughput and mechanistic analysis.

2018-05-10 | GSE113741 | GEO

Molecular characterization of neuroendocrine prostate cancer organoids and PDOX by RNA-seq

Project description:We report the generation and characterization of tumor organoids and PDOX derived from needle biopsies of metastatic lesions from neuroendocrine prostate cancer patients.

2018-06-22 | GSE112786 | GEO